Publications by authors named "Chenggong Guan"
Article Synopsis
- Traditional Chinese herbal medicines (TCMs) are increasingly used with conventional pharmaceuticals, but concerns about cutaneous adverse drug reactions (CADRs) exist, especially in conjunction with antibiotics and NSAIDs.
- A study reviewed data from over 1.8 million patient visits from 2007 to 2022 to assess the frequency and severity of CADRs when TCMs were used alongside these medications.
- Findings indicate TCMs do not significantly increase severe CADRs when combined with antibiotics or NSAIDs, suggesting their safe use in multi-drug therapies, but ongoing monitoring and regulation are essential for drug safety.
Interstitial lung disease (ILD) has been identified as a prevalent complication and significant contributor to mortality in individuals with pemphigus. In this study, a murine model of pemphigus was developed through the subcutaneous administration of serum IgG obtained from pemphigus patients, allowing for an investigation into the association between pemphigus and ILD. Pulmonary interstitial lesions were identified in the lungs of a pemphigus mouse model through histopathology, RT-qPCR and Sircol assay analyses.
View Article and Find Full Text PDFPurpose: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy was investigated to determine whether it is superior to N-Acetylcysteine (NAC) for the treatment of patients with early-stage ILD.
Patients And Methods: A prospective, single-center, randomized, controlled clinical trial was conducted in 87 patients with early-stage ILD.