Self-Assembly Behavior of Collagen and Its Composite Materials: Preparation, Characterizations, and Biomedical Engineering and Allied Applications.

Collagen is the oldest and most abundant extracellular matrix protein and has many applications in biomedical, food, cosmetic, and other industries. Previous reviews have already introduced collagen's sources, structures, and biosynthesis. The biological and mechanical properties of collagen-based composite materials, their modification and application forms, and their interactions with host tissues are pinpointed.

Collagen/functionalized cellulose nanofibril composite aerogels with pH-responsive characteristics for drug delivery system.

In this work, carboxylated and amination modified cellulose nanofibrils (CNFs) were fabricated via the TEMPO catalytic oxidation system and diethylenetriamine, and collagen composite aerogels were fabricated through a simple self-assembly pretreatment and directional freeze-drying technology. Morphology analysis showed that the collagen composite aerogels had distinct layered-oriented double network structures after the self-assembly pretreatment. The intermolecular interactions between the collagen fibrils and functionalized CNFs (fCNFs) on the structures and properties of the composite aerogels were also examined through various characterization techniques.

Self-assembly of collagen fibrils on graphene oxide and their hybrid nanocomposite films.

In order to explore the distribution, conformation and interaction of collagen on GO nanosheet surfaces, the mechanism of self-assembly of collagen was investigated in the presence of GO nanosheets. Atomic force microscopy (AFM) was employed to observe the conformation of self-assembled collagen fibrils on the GO nanosheets surfaces. The collagen concentration and incubation time mainly affect the size of the collagen fibrils while the pH of the dispersion determines the self-assembly sites of collagen fibrils on the GO nanosheets surfaces.

Effects of the aspect ratio of multi-walled carbon nanotubes on the structure and properties of regenerated collagen fibers.

Collagen is a natural one-dimensional nanomaterial. Multi-walled carbon nanotubes (MWNTs) have been previously shown to interact with biomolecules and to have promising applications in reinforced biopolymers for tissue engineering and regenerative medicine. In this work, collagen/MWNT composite fibers are prepared using dry-jet wet-spinning technology.