Young children form generalized attitudes based on a single encounter with an outgroup member.

The goal of the present research was to assess whether children's first interaction with a single outgroup member can significantly impact their general attitudes toward the outgroup as a whole. In two preregistered studies, 5- to 6-year-old Chinese children (total N = 147) encountered a Black adult from another country for the very first time, and they played a game together. General attitudes toward the outgroup were assessed using both implicit and explicit measures.

Shaping children's racial bias through interpersonal movement.

The early emergence of racial biases points to the urgent need to understand how interpersonal experiences might shape them. We examined whether interpersonal movement shapes racial biases among 4- to 6-year-old Chinese children who had no prior contact with Black people. In Experiment 1 (N = 134), children played a musical game, moving either in or out of synchrony with a Chinese or Black adult.

Lattice-strain control of the activity in dealloyed core-shell fuel cell catalysts.

Electrocatalysis will play a key role in future energy conversion and storage technologies, such as water electrolysers, fuel cells and metal-air batteries. Molecular interactions between chemical reactants and the catalytic surface control the activity and efficiency, and hence need to be optimized; however, generalized experimental strategies to do so are scarce. Here we show how lattice strain can be used experimentally to tune the catalytic activity of dealloyed bimetallic nanoparticles for the oxygen-reduction reaction, a key barrier to the application of fuel cells and metal-air batteries.

Size and composition distribution dynamics of alloy nanoparticle electrocatalysts probed by anomalous small angle X-ray scattering (ASAXS).

Anomalous small angle X-ray scattering (ASAXS) is shown to be an ideal technique to investigate the particle size and particle composition dynamics of carbon-supported alloy nanoparticle electrocatalysts at the atomic scale. In this technique, SAXS data are obtained at different X-ray energies close to a metal absorption edge, where the metal scattering strength changes, providing element specificity. ASAXS is used to, first, establish relationships between annealing temperature and the resulting particle size distribution for Pt25Cu75 alloy nanoparticle electrocatalyst precursors.

Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells.

Terfenadine (TF), a highly potent histamine H1 receptor antagonist, has been shown to exert no significant central nervous system side effects in clinically effective doses. In this study, we demonstrated that TF induced significant growth inhibition of human cancer cells, including Hep G2, HT 29, and COLO 205 cells, through induction of G(0)/G(1) phase cell-cycle arrest. The minimal dose of TF induced significant G(0)/G(1) arrest in these cells was 1-3 microM.

Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity.

Terfenadine (TF) is a highly potent histamine H1 receptor antagonist that in clinically effective doses is free of significant central nervous system side effects. Ketoconazole (KT) is a worldwide used oral antifungal agent with a broad spectrum of activity against both superficial and systemic mycosis. Simultaneously administration of KT and TF has been reported to induce several potent symptoms including cardiotoxicity, excitotoxicity, inhibition of blood mononuclear cells proliferation, and cardiovascular toxicity.