Publications by authors named "Chengen Han"
Article Synopsis
- Pneumonia (MPP) is common in children, and the rising resistance of Mycoplasma pneumoniae (MP) to antibiotics highlights the need for new treatments, such as Yinqin Qingfei granules (YQQFG), a Chinese medicine with unclear mechanisms.
- Researchers identified 25 bioactive components in YQQFG that effectively target the NLRP3/Caspase-1/GSDMD pathway, which plays a role in inflammation caused by MP.
- Studies showed that YQQFG reduces harmful cytokines (IL-1β and IL-18) and MP exotoxin release, suggesting it could serve as a promising therapeutic option for pediatric pneumonia.
Background: pneumonia (MPP), attributable to (MP), represents a predominant form of community-acquired pneumonia in pediatric populations, thereby posing a significant threat to pediatric health. Given the burgeoning volume of research literature associated with pediatric MPP in recent years, it becomes imperative to undertake a bibliometric analysis aimed at delineating the current research landscape and emerging trends, thereby furnishing a framework for subsequent investigations.
Methods: A comprehensive literature search targeting pediatric MPP was conducted in the Web of Science Core Collection.
Background: Polygoni Cuspidati Rhizoma et Radix (PCRR), a well-known traditional Chinese medicine (TCM), inhibits inflammation associated with various human diseases. However, the anti-inflammatory effects of PCRR in acute lung injury (ALI) and the underlying mechanisms of action remain unclear.
Aim: To determine the ingredients related to PCRR for treatment of ALI using multiple databases to obtain potential targets for fishing.
Objective: Gastrodin is a main medicinal component of traditional Chinese medicine (TCM) Blume (), presenting the potential for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, the underlying targets and action mechanisms of the treatment have not been identified.
Methods: The gastrodin-related microarray dataset GSE85871 was obtained from the GEO database and analyzed by GEO2R to obtain differentially expressed genes (DEGs).