Advanced liver fibrosis, but not MASLD, is associated with accelerated biological aging: a population-based study.

Background: The process of biological aging in patients diagnosed with chronic liver disease remains unclear.

Aim: The current study aims to investigate if there is an accelerated biological aging process in participants with advanced fibrosis (AF) and metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: Data from the 2017-2018 NHANES cycle were analyzed.

MitoQ protects against carbon tetrachloride-induced hepatocyte ferroptosis and acute liver injury by suppressing mtROS-mediated ACSL4 upregulation.

Ferroptosis has been shown to be involved in carbon tetrachloride (CCl)-induced acute liver injury (ALI). The mitochondrion-targeted antioxidant MitoQ can eliminate the production of mitochondrial reactive oxygen species (mtROS). This study investigated the role of MitoQ in CCl-induced hepatocytic ferroptosis and ALI.

1,25(OH)D alleviates oxidative stress and inflammation through up-regulating HMGCS2 in DSS-induced colitis.

Background: Previous study found that supplements with active vitamin D3 alleviated experimental colitis. The objective of this study was to investigate the possible role of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), a ketone synthase, on vitamin D3 protecting against experimental colitis.

Methods: HMGCS2 and vitamin D receptor (VDR) were measured in UC patients.

A novel molecular mechanism mediated by circCCDC134 regulates non-small cell lung cancer progression.

Background: Circular RNA (circRNA) plays a crucial role in non-small cell lung cancer (NSCLC) progression. However, the role of circCCDC134 in NSCLC is still largely unknown.

Methods: Quantitative real-time PCR was utilized for measuring circCCDC134, microRNA (miR)-625-5p and nuclear factor of activated T cell 5 (NFAT5) expression.

Risk factors of recurrent choledocholithiasis following therapeutic endoscopic retrograde cholangiopancreatography.

Background: The risk factors for the recurrent choledocholithiasis after endoscopic retrograde cholangiopancreatography (ERCP) have not been well studied. The aim of this study was to explore the risk factors of recurrent choledocholithiasis.

Methods: We carried out a retrospective analysis of data collected between January 1, 2010 and January 1, 2020.

m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma.

Background: The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain unclear.

Methods: We systematically investigated the modification patterns of 10 m1A regulators in HCC samples and evaluated the metabolic characteristics of each pattern.

A potential novel biomarker in predicting lymph node metastasis of gastric signet ring cell carcinoma: A derived monocyte to lymphocyte ratio.

Background: This study is designed to evaluate the predictive value of derived monocyte to lymphocyte ratio (dMLR), neutrophil to lymphocyte ratio (NLR) and eosinophil to lymphocyte ratio (ELR) for lymph node metastasis (LNM) in gastric signet ring cell carcinoma (SRCC) patients.

Methods: We carried out a retrospective analysis for 203 eligible patients who underwent radical gastrectomy between January 2011 and September 2020.

Results: The diagnostic sensitivity and specificity for dMLR were 60.

[A comparative study of phenoloxidase activity between and ].

Objective: To study the differences of the phenoloxidase (PO) relative activity among ribbed shelled , smooth shelled and .

Methods: The crude PO fluid was extracted from the soft tissue of and by homogenation and centrifugation. The PO activity was detected with catechol as the substrate in the reaction systems.