Synergistic effect of drug/antibiotic-impregnated micro/nanohybrid mesoporous bioactive glass/calcium phosphate composite bone cement on antibacterial and osteoconductive activities.

Calcium phosphate bone cements (CPC) can be used in minimally invasive surgery because of their injectability, and they can also be used to repair small and irregular bone defects. This study aimed to release the antibiotic gentamicin sulfate (Genta) to reduce tissue inflammation and prevent infection in the early stages of bone recovery. Subsequently, the sustained release of the bone-promoting drug ferulic acid (FA) mimicked the response of osteoprogenitor D1 cells interaction, thereby accelerating the healing process of the overall bone repair.

Tau -Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model.

The microtubule-associated protein tau can undergo liquid-liquid phase separation (LLPS) to form membraneless condensates in neurons, yet the underlying molecular mechanisms and functions of tau LLPS and tau droplets remain to be elucidated. The human brain contains mainly 6 tau isoforms with different numbers of microtubule-binding repeats (3R, 4R) and -terminal inserts (0, 1, 2). However, little is known about the role of -terminal inserts.

Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands.

Alzheimer's disease is a neurodegenerative disease which severely impacts the health of the elderly. Current treatments are only able to alleviate symptoms, but not prevent or cure the disease. The neurofibrillary tangles formed by tau protein aggregation are one of the defining characteristics of Alzheimer's disease, so tau protein has become a key target for the drug design.

Stereoselective Degradation and Transformation Products of a Novel Chiral Insecticide, Paichongding, in Flooded Paddy Soil.

Paichongding is a chiral neonicotinoid insecticide currently marketed as racemate against sucking and biting insects. Under anaerobic condition, all paichongding stereoisomers underwent appreciable degradation in soil during 100 days of incubation, with estimated t values between 0.18 and 3.

Enantioselective absorption and transformation of a novel chiral neonicotinoid [(14)C]-cycloxaprid in rats.

Neonicotinoid pesticides caused hazardous effects on pollinators and aquatic ecosystem. The new developed chiral cis-neonicotinoid cycloxaprid(CYC) is a highly potent substitute for low toxicity to bees and high efficiency on target-insects, but little is known about the metabolic dynamics of racemic CYC and its 2 enantiomers(SR and RS) in animal models. In this study, chiral separation of (14)C-labeled racemic CYC was performed in high-performance liquid chromatography under optimal conditions.

Enhancement effect of ethanol on lipid and fatty acid accumulation and composition of Scenedesmus sp.

The effects of ethanol concentration gradients along with varied cultivation times on lipid and fatty acid accumulation and composition of Scenedesmus sp. were studied. The maximum increment of algal density, lipid productivity, lipid content and fatty acid content were 6.

Two new species of Gieysztoria (Platyhelminthes, Rhabdocoela, Dalyelliidae) from a freshwater artificial lake in Shenzhen, China.

Two new species of the "Aequales" of genus Gieysztoria were collected and described from an artificial lake on the Shenzhen University campus. Gieysztoria bimaculata n. sp.