Copolymerization of Natural Camphor-Derived Rigid Diol with Various Dicarboxylic Acids: Access to Biobased Polyesters with Various Properties.

In this work, alicyclic (1,3)-1,2,2-trimethylcyclopentane-1,3-dimethanol (TCDM), derived from natural camphor, was copolymerized with linear α,ω-diacids, terephthalic acid (TPA), and 2,5-furandicarboxylic acid (FDCA), affording a series of polyesters with functional properties. 2D NMR spectroscopy revealed that the stereoconfiguration of TCDM was preserved after polymerization. The TCDM polyester based on TPA showed high thermostability, high value (115 °C), high modulus (1.

Construction of an Antibacterial Membrane Based on Dopamine and Polyethylenimine Cross-Linked Graphene Oxide.

Bacterial infections have been considered to be one of the greatest threats to human health. In this study, a covalently cross-linked GO membrane was fabricated through vacuum-assisted filtration self-assembly after being consequentially functionalized with dopamine (GO-PDA) and branched polyethylenimine (GO-PDA-PEI). The characteristics of GO, GO-PDA, and GO-PDA-PEI membranes were confirmed by X-ray diffraction, Fourier transform infrared measurements, scanning electron microscopy images, static water contact angle measurements, etc.

Copolycarbonates Based on a Bicyclic Diol Derived from Citric Acid and Flexible 1,4-Cyclohexanedimethanol: From Synthesis to Properties.

Octahydro-2,5-pentalenediol (OPD), is a compelling citric acid-based bicyclic diol with excellent rigidity and thermal stability. Herein, a series of copolycarbonates (co-PCs) were synthesized, starting from OPD, 1,4-cyclohexanedimethanol (CHDM), and diphenyl carbonate (DPC). All polycarbonates are amorphous with glass transition temperatures increased when increasing the content in OPD units.

A multifunctional polymeric gene delivery system for circumventing biological barriers.

Aiming to circumvent the pre-defined obstacles in the journey of gene transportation, we attempt to compile a number of functional components into a tandem tri-copolymeric material. Herein, a β-cyclodextrin-functionalized poly(glycerol methacrylate) (PG) segment and a quaternary amine-functionalized poly[(2-acryloyl)-ethyl-(p-boronic acid pinacol ester benzyl)diethylammonium bromide] (BP) segment are attached to complex DNA to formulate a nanoscaled delivery system based on electrostatic interactions. The formulated polyplex is strengthened by a hydrophobic poly[2-(5,5-dimethyl-1,3-dioxan-2-yloxy)ethyl acrylate] (PDM) segment, affording improved complex stability.

Construction of Bovine Serum Albumin/AIE-Based Quaternary Complexes for Efficient Gene Transfection.

High transfection efficiency and superior cell imaging are required for cationic polymers-based gene delivery system to afford high therapeutic effect but its high toxicity and unstable cell imaging are easily ignored. In this study, cationic amino poly(glycerol methacrylate) derivative (PGMA-EDA) is used to incorporate bovine serum albumin (BSA) and aggregation-induced emission (AIE) molecular (tetraphenylethylene derivatives, TPE) as an efficient carrier for gene transfection and intracellular imaging. The obtained polymer/pDNA-TPE/BSA (PDTB) quaternary nanoparticles (NPs) not only exhibit efficient gene transfection but also show excellent biocompatibility.

Construction of coumarin-based cross-linked micelles with pH responsive hydrazone bond and tumor targeting moiety.

It is still a major challenge for targeted cancer chemotherapy to design a stable biocompatible micellar drug delivery system. To address this dilemma, novel responsive cross-linked micelles (x-micelles) based on polyurethane with photo-responsive coumarin derivatives and pH-responsive hydrazone groups were synthesized. The polymers could be self-assembled into micelles using a typical and facile way.