Lead regulation of electronic properties and local structure of palladium (111) facet for enhanced direct hydrogen peroxide synthesis.

Direct synthesis of hydrogen peroxide (DSHP) from oxygen (O) and hydrogen (H) offers a promising alternative to anthraquinone oxidation for hydrogen peroxide (HO) production, yet challenges remain in achieving high selectivity and productivity. In this study, palladium octahedral nanoparticles (Pd ONPs) exposing Pd(111) facets were first synthesized, followed by the introduction of lead (Pb) atoms onto these facets to construct Pb-Pd(111) surface alloy structures (Pd@Pd-Pbx ONPs) for efficient DSHP. Characterization results indicated that the introduction of Pb atoms increased the electron density of Pd atoms and significantly reduced the number of low-coordinated Pd atoms.

Regulating local molecular polarization of triazine-PDI based polymer for high-efficient photocatalytic coupling of benzylamine.

Designing a robust built-in electric field (BF) is a charming strategy for enhancing the separation and transportation of charges via introducing large π-conjugated molecules. However, it has flexible or semiflexible geometries, which significantly disorder the crystalline and deteriorated the built-in electric field. Here, a straightforward tactic for creating a cyano-functionalized smaller D (benzene) - A (triazine) units in PDI- triazine based polymer (PDIMB) to enhance intrinsic molecule dipole has been proposed.

GATA-1 Promotes Erythroid Differentiation Through the Upregulation of and Expressions in CD34 Cells in High-Altitude Polycythemia.

Liu, Fang, Caiyan Hu, Jin Ding, Chengbing Fu, Shuqiong Wang, and Tiantian Li. GATA-1 promotes erythroid differentiation through the upregulation of and expression in CD34 cells in high-altitude polycythemia. .

A simple and effective method to purify and activate T cells for successful generation of chimeric antigen receptor T (CAR-T) cells from patients with high monocyte count.

Background: Chimeric antigen receptor T (CAR-T) cells are genetically modified T cells with redirected specificity and potent T-cell-mediated cytotoxicity toward malignant cells. Despite several CAR-T products being approved and commercialized in the USA, Europe, and China, CAR-T products still require additional optimization to ensure reproducible and cost-effective manufacture. Here, we investigated the critical parameters in the CD3 T-cell isolation process that significantly impacted CAR-T manufacturing's success.

Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia.

GATA binding protein 1 (GATA‑1) is one of the most important hematopoietic transcription factors in the production of blood cells, such as platelets, eosinophils, mast cells and erythrocytes. GATA‑1 regulates the participation of microRNA (miRNAs/miRs) in erythroid differentiation under normoxia. However, GATA‑1 expression and the regulation of miR‑210‑3p in the context of erythroid differentiation under hypoxia remain unknown.

[Effect of MiR-451a on Erythroid Differentiation of K562 Cells under Hypoxia].

Objective: To investigate the changes of GATA-1 protein expression during erythroid differentiation of K562 cells under hypoxia and how GATA-1 can regulate erythroid differentiation by up-regulating the expression of miR-451a and inhibiting the expression of 14-3-3ζ.

Methods: K562 cells were divided into 2 groups: the normoxia group and the hypoxia group, after the induction of hemin for 96 h, the positive cells rate of the benzidine staining, the mRNA expression of γ-globin and the expression of CD235a were detected, and the success of the model was verified. The changes of GATA-1 and miR-451a expression in the above-mentioned 2 groups, the changes of miR-451a expression after over-expressed GATA-1 were detected by Western blot and qRT-PCR.