Correlation of 18F-FDG PET/CT metabolic parameters with Ki-67 expression and tumor staging in nasopharyngeal carcinoma.

Purpose: The study aimed to investigate the imaging parameters of 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography (PET/CT) in nasopharyngeal carcinoma (NPC), specifically examining the relationship between mean standardized uptake value (SUVmean), maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) with Ki-67 expression, T-stage, and tumor node metastasis (TNM) stage.

Methods: A retrospective analysis was conducted on 143 consecutive NPC patients from January 2015 to December 2023 who underwent 18F-FDG PET/CT for initial disease assessment. SUVmax, SUVmean, MTV, and TLG were quantified from PET/CT images.

Enhanced detection of skull-base bone invasion in nasopharyngeal carcinoma: the supplementary diagnostic value of fluorine-sodium fluoride (F-NaF) positron emission tomography/computed tomography (PET/CT) combined with magnetic resonance imaging (MRI).

Background: Nasopharyngeal carcinoma (NPC) originates in the nasopharyngeal mucosa, the lateral wall of the nasopharynx. A significant challenge in NPC management is skull-base bone invasion (SBBI), which affects prognosis and treatment planning. Magnetic resonance imaging (MRI) is the primary diagnostic tool for SBBI in NPC patients; however, the detection of SBBI can be challenging due to skull-base complexity and overlapping MRI signals.

The potential advantages of F sodium fluoride positron emission tomography-computed tomography for clinical staging and management planning in patients with nasopharyngeal carcinoma.

Background: The staging and treatment planning of nasopharyngeal carcinoma (NPC) face challenges due to limited sensitivity of conventional imaging. F-sodium fluoride (F-NaF) positron emission tomography-computed tomography (PET/CT) offers potential advantages in detecting early bone involvement. This retrospective cohort study aimed to assess the potential advantage of F-NaF PET/CT for clinical staging and management planning in patients with NPC and to compare F-NaF PET/CT findings with those of conventional imaging modalities.

The value of F-NaF PET/CT in the diagnosis of bone metastases in patients with nasopharyngeal carcinoma using visual and quantitative analyses.

To assess the diagnostic value of F-NaF PET/CT in diagnosing bone metastases in patients with nasopharyngeal carcinoma (NPC) using visual and quantitative analyses. 164 patients with NPC who underwent F-NaF PET/CT between 2017 and 2021 were included. The sensitivity, specificity, and accuracy were calculated.

Comparison of Bone Metastases between F-NaF PET/CT, F-NaF PET, and Planar Tc-MDP Bone Scintigraphy in Patients with Newly Diagnosed Nasopharyngeal Carcinoma.

Purpose: Our study aims to compare the diagnostic value of F-NaF positron emission tomography-computed tomography (PET/CT), F-NaF PET, and planar Tc-MDP bone scintigraphy for detection of bone metastases in patients with newly diagnosed nasopharyngeal carcinoma (NPC).

Methods: Our study retrospectively analyzed 58 patients with pathologically proven NPC. They all underwent both F-NaF PET/CT and planar Tc-MDP bone scintigraphy within a 7-day interval.