Bifunctional modified bacterial cellulose-based hydrogel through sequence-dependent crosslinking towards enhanced antibacterial and cutaneous wound healing.

Chronic wounds caused by microbial infection have emerged as a major challenge on patients and medical health system. Bacterial cellulose (BC) characterized by its excellent biocompatibility and porous network, holds promise for addressing complex wound issues. However, lack of inherent antibacterial activity and cross-linking sites in the molecular network of BC have constrained its efficacy in hydrogel design and treatment of bacterial-infected wounds.

Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair.

Complete spinal cord injury (SCI) causes permanent locomotor, sensory and neurological dysfunctions. Targeting complex immunopathological microenvironment at SCI sites comprising inflammatory cytokines infiltration, oxidative stress and massive neuronal apoptosis, the conductive oriented nanofiber felt with efficient ROS clearance, anti-inflammatory effect and accelerating neural regeneration is constructed by step-growth addition polymerization and electrostatic spinning technique for SCI repair. The formation of innovative Fe-PDA-PAT chelate in nanofiber felt enhances hydrophilic, antioxidant, antibacterial, hemostatic and binding factor capacities, thereby regulating immune microenvironment of SCI.

Do Health Literate Older People Have Fewer Depressive Symptoms? Evidence from the Urban Areas of Western China.

Background: Previous research has indicated that health literacy has a good influence on the mental health among older adults. The current study aims to determine whether health literacy is linked to depressive symptoms in older adults in west China, and tries to detect the mechanisms underlying the linkage between health literacy and depressive symptoms in the Chinese context.

Methods: Study data were obtained from a cross-sectional ageing health literacy survey conducted in 2017 in Western China, and 812 urban individuals aged 60 and older were selected.

Scalable Electro-Biosynthesis of Ectoine from Greenhouse Gases.

Converting greenhouse gases into valuable products has become a promising approach for achieving a carbon-neutral economy and sustainable development. However, the conversion efficiency depends on the energy yield of the substrate. In this study, we developed an electro-biocatalytic system by integrating electrochemical and microbial processes to upcycle CO into a valuable product (ectoine) using renewable energy.

Temperature-responsive self-contraction nanofiber/hydrogel composite dressing facilitates the healing of diabetic-infected wounds.

Bacterial infections and long-term inflammation cause serious secondary damage to chronic diabetic wounds and hinder the wound healing processes. Currently, multifunctional hydrogels have shown promising effects in chronic wound repair. However, traditional hydrogels only keep the wound moist and protect it from bacterial infection, and cannot provide mechanical force to contract the wound edges to achieve facilitated wound closure.

Ruthenium Single-Atom Modulated Protonated Iridium Oxide for Acidic Water Oxidation in Proton Exchange Membrane Electrolysers.

Proton exchange membrane water electrolysers promise to usher in a new era of clean energy, but they remain a formidable obstacle in designing active and durable electrocatalysts for the acidic oxygen evolution reaction (OER). In this study, a protonated iridium oxide embedded with single-atom dispersed ruthenium atoms (HIr RuO) that demonstrates exceptional activity and stability in acidic water oxidation is introduced. The single Ru dopants favorably induce localized oxygen vacancies in the Ir─O lattice, synergistically strengthening the adsorption of OOH* intermediates and enhancing the intrinsic OER activity.

Difluorocarbene-induced [1,2]- and [2,3]-Stevens rearrangement of tertiary amines.

The [1,2]- and [2,3]-Stevens rearrangements are one of the most fascinating chemical bond reorganization strategies in organic chemistry, and they have been demonstrated in a wide range of applications, representing a fundamental reaction tactic for the synthesis of nitrogen compounds in chemical community. However, their applicabilities are limited by the scarcity of efficient, general, and straightforward methods for generating ammonium ylides. Herein, we report a general difluorocarbene-induced tertiary amine-involved [1,2]- and [2,3]-Stevens rearrangements stemmed from in situ generated difluoromethyl ammonium ylides, which allows for the rearrangements of versatile tertiary amines bearing either allyl, benzyl, or propargyl groups, resulting in the corresponding products in one reaction under the same reaction conditions with a general way.

Selective Integrating Molecular Catalytic Units into Bipyridine-Based Covalent Organic Frameworks for Specific Photocatalytic Fuel Production.

Molecular metal compounds have demonstrated excellent catalytic activity and product selectivity in the H evolution reaction (HER) and the CO reduction reaction (CORR). The heterogenization of molecular catalysts is regarded as an effective approach to improve their applicability. In this work, the molecular catalytic units [Cp*Ir(Bpy)Cl] and [Ru(Bpy)(CO)Cl] are constructed in situ on the bipyridine sites of the covalent organic framework for photocatalytic HER and CORR, respectively.

Polysaccharide-Based Coating with Excellent Antibiofilm and Repeatable Antifouling-Bactericidal Properties for Treating Infected Hernia.

In recent years, the utilization of medical devices has gradually increased and implantation procedures have become common treatments. However, patients are susceptible to the risk of implant infections. This study utilized chemical grafting to immobilize polyethylenimine (QPEI) and hyaluronic acid (HA) on the surface of the mesh to improve biocompatibility while being able to achieve antifouling antimicrobial effects.

Treatment of rheumatoid arthritis with curcumin analog 3,5-bis(arylidene)-4-piperidone.

Rheumatoid arthritis (RA) is an inflammatory disease. Curcumin can inhibit NF-κB and reduce the expression of inflammation-related genes. To evaluate the potential development of in the clinical treatment of inflammatory diseases such as RA.

Neuroprotective Effects of Leptin on the APP/PS1 Alzheimer's Disease Mouse Model: Role of Microglial and Neuroinflammation.

Background: Microglia are closely linked to Alzheimer's disease (AD) many years ago; however, the pathological mechanisms of AD remain unclear. The purpose of this study was to determine whether leptin affected microglia in the hippocampus of young and aged male APP/PS1 mice.

Objective: In a transgenic model of AD, we investigated the association between intraperitoneal injection of leptin and microglia.

Mn(iii)-mediated C-P bond activation of diphosphines: toward a highly emissive phosphahelicene cation scaffold and modulated circularly polarized luminescence.

Transition metal mediated C-X (X = H, halogen) bond activation provides an impressive protocol for building polyaromatic hydrocarbons (PAHs) in C-C bond coupling and annulation; however, mimicking both the reaction model and Lewis acid mediator simultaneously in a hetero-PAH system for selective C-P bond cleavage faces unsolved challenges. At present, developing the C-P bond activation protocol of the phosphonic backbone using noble-metal complexes is a predominant passway for the construction of phosphine catalysts and P-center redox-dependent photoelectric semiconductors, but non-noble metal triggered methods are still elusive. Herein, we report Mn(iii)-mediated C-P bond activation and intramolecular cyclization of diphosphines by a redox-directed radical phosphonium process, generating phosphahelicene cations or phosphoniums with nice regioselectivity and substrate universality under mild conditions.

Regulating the Content of Donor Unit in Donor-Acceptor Covalent Triazine Frameworks for Promoting Photocatalytic H Production.

Using their own triazine groups as natural receptors, the introduction of various donor units to construct donor-receptor configuration in covalent triazine frameworks (CTFs) has been shown to be an effective strategy to improve photocatalytic activity. In this work, the effect of donor unit content (D-content) on the photoelectric properties and photocatalytic activity of CTFs was thoroughly investigated. Four analogous CTFs with different D-content have been rationally designed and synthesized, in which the bithiophene (Btp) as the donor unit and triazine as the acceptor unit.

Decarboxylation of β-boryl NHPI esters enables radical 1,2-boron shift for the assembly of versatile organoborons.

In recent years, numerous 1,2-R shift (R = aliphatic or aryl) based on tetracoordinate boron species have been well investigated. In the contrary, the corresponding radical migrations, especially 1,2-boryl radical shift for the construction of organoborons is still in its infancy. Given the paucity and significance of such strategies in boron chemistry, it is urgent to develop other efficient and alternative synthetic protocols to enrich these underdeveloped radical 1,2-boron migrations, before their fundamental potential applications could be fully explored at will.

Effect of Grain Structure and Quenching Rate on the Susceptibility to Exfoliation Corrosion in 7085 Alloy.

The influence of grain structure and quenching rates on the exfoliation corrosion (EXCO) susceptibility of 7085 alloy was studied using immersion tests, optical microscopy (OM), scanning electron microscopy (SEM), electron backscatter diffraction (EBSD), and scanning transmission electron microscopy (STEM). The results show that as the cooling rate decreases from 1048 °C/min to 129 °C/min; the size of grain boundary precipitates (GBPs); the width of precipitate-free zones (PFZ); and the content of Zn, Mg, and Cu in GBPs rise, leading to an increase in EXCO depth and consequently higher EXCO susceptibility. Meanwhile, there is a linear relationship between the average corrosion depth and the logarithm of the cooling rate.

Low complexity joint clock recovery and adaptive equalization based on a baud-rate timing phase error detector for short-reach digital coherent transmission.

Digital coherent receivers adopting joint clock recovery and adaptive equalization (JCA) can avoid failures of the adaptive equalizer (AEQ) or clock recovery algorithm (CRA) due to clock asynchrony and chromatic dispersion (CD). But in the previous JCA scheme, the AEQ has a heavy computational load as it has to generate two samples per symbol (SPS) for the subsequent timing phase error detector (TPED) which is the core of the CRA. Furthermore, the previous JCA scheme cannot compensate for receiver skew or accommodate Nyquist signals with small roll-off factors (ROFs).

Surface passivation for highly active, selective, stable, and scalable CO electroreduction.

Electrochemical conversion of CO to formic acid using Bismuth catalysts is one the most promising pathways for industrialization. However, it is still difficult to achieve high formic acid production at wide voltage intervals and industrial current densities because the Bi catalysts are often poisoned by oxygenated species. Herein, we report a BiS nanowire-ascorbic acid hybrid catalyst that simultaneously improves formic acid selectivity, activity, and stability at high applied voltages.

Embryonic perfect repair inspired electrospun nanofibers dressing with temperature-sensitive and antibacterial properties for wound healing.

Introduction: The development of highly effective wound dressings is crucial for successful clinical applications. Achieving wound closure, preventing infection, and minimizing scarring are key objectives in wound healing. Drawing inspiration from the regenerative mechanisms observed in embryonic tissue repair, we designed a series of wound-contractible dressings with exceptional antibacterial properties.

Time-domain low-complexity clock recovery for non-integer oversampled Nyquist signals with a small roll-off factor.

A clock recovery algorithm (CRA) suitable for non-integer oversampled Nyquist signals with a small roll-off factor (ROF) is appealing to short-reach high-speed inter-datacenter transmission systems which need to cut down the transceiver power consumption and cost by reducing the oversampling factor (OSF) and using cheap low-bandwidth components. However, due to the lack of a suitable timing phase error detector (TPED), CRAs proposed now fail for non-integer OSFs below two and small ROFs close to zero and are not hardware-efficient. To solve these problems, we propose a low-complexity TPED by modifying the time-domain quadratic signal and reselecting the synchronization spectral component.

Thermal Deformation Behavior and Dynamic Softening Mechanisms of Zn-2.0Cu-0.15Ti Alloy: An Investigation of Hot Processing Conditions and Flow Stress Behavior.

Through isothermal hot compression experiments at various strain rates and temperatures, the thermal deformation behavior of Zn-2.0Cu-0.15Ti alloy is investigated.

Multifunctional xyloglucan-containing electrospun nanofibrous dressings for accelerating infected wound healing.

Preventing wound infection is a major challenge in biomedicine. Conventional wound dressings often have poor moisturizing and antimicrobial properties unfavorable for wound healing. In this study, we prepared a multifunctional electrospun nanofiber dressing (PCQX-M) containing xyloglucan, quaternized chitosan, Polyvinyl alcohol, and collagen.

Applications of Metal-Organic Frameworks and Their Derivatives in Electrochemical CO Reduction.

Electrochemically reducing CO to more reduced chemical species is a promising way that not only enables the conversion of intermittent energy resources to stable fuels, but also helps to build a closed-loop anthropogenic carbon cycle. Among various electrocatalysts for electrochemical CO reduction, multifunctional metal-organic frameworks (MOFs) have been employed as highly efficient and selective heterogeneous electrocatalysts due to their ultrahigh porosity and topologically diverse structures. Up to now, great progress has been achieved in the design and synthesis of highly active and selective MOF-related catalysts for electrochemical CO reduction reaction (CORR), and their corresponding reaction mechanisms have been thoroughly studied.

Self-Healing Hydrogels Fabricated by Introducing Antibacterial Long-Chain Alkyl Quaternary Ammonium Salt into Marine-Derived Polysaccharides for Wound Healing.

The development of hydrogels as wound dressings has gained considerable attention due to their promising ability to promote wound healing. However, in many cases of clinical relevance, repeated bacterial infection, which might obstruct wound healing, usually occurs due to the lack of antibacterial properties of these hydrogels. In this study, we fabricated a new class of self-healing hydrogel with enhanced antibacterial properties based on dodecyl quaternary ammonium salt (Q12)-modified carboxymethyl chitosan (Q12-CMC), aldehyde group- modified sodium alginate (ASA), Fe via Schiff bases and coordination bonds (QAF hydrogels).

Intestinal tuberculosis presented as spindle cell pseudotumor in a HIV-positive case.

MSP is a rare and atypical form of benign granulomatous inflammation characterised by tumour-like local proliferation of spindle-shaped histiocytes containing acid-fast positive mycobacteria, which should be differentiated from neoplastic lesions. A 26-year-old Chinese man complained an intermittent and mild right lower abdominal pain for 5 months in May 2022.Histopathology of biopsy samples showed Mycobacterial spindle cell pseudotumor (MSP).

A nanofiber/sponge double-layered composite membrane capable of inhibiting infection and promoting blood coagulation during wound healing.

Uncontrolled bleeding and bacterial infections cause severe damage to the wounds and remain a clinical challenge. Here, we developed a nanofiber/sponge bilayered composite membrane (QCP) containing quaternized silicone (QP12) and quaternized chitosan (QCS12) by joint approaches of electrospinning and freeze-drying and investigated their potential for wound dressing. The QCP was composed of a sponge (QCC) containing collagen (COL) and QCS12 and a nanofibrous membrane (MQP) containing poly-ε-caprolactone (PCL) and QP12.