rearrangements are recognized drivers in lung cancer, representing a small subset (1-2%) of non-small cell lung cancer (NSCLC). Additionally, fusions also serve as a rare acquired resistance mechanism in -mutant NSCLC. Only a few NSCLC cases have been reported with co-occurrence of mutations and fusions as an acquired resistance mechanism induced by EGFR-tyrosine kinase inhibitors (TKIs).
View Article and Find Full Text PDFArctigenin, one of the active ingredients extracted from Great Burdock (Arctium lappa) Achene, has been found to relieve myocardial infarction injury. However, the specific mechanism of Arctigenin against myocardial infarction remains largely unknown. Here, both acute myocardial ischemia-reperfusion injury (AMI/R) rat model and oxygen glucose deprivation (OGD)-induced myocardial cell injury model were constructed to explore the underlying role of AMPK/SIRT1 pathway in Arctigenin-mediated effects.
View Article and Find Full Text PDFObjective: To summary the recent advances in molecular research of glioblastoma (GBM) and current trends in personalized therapy of this disease.
Data Sources: Data cited in this review were obtained mainly from PubMed in English up to 2015, with keywords "molecular", "genetics", "GBM", "isocitrate dehydrogenase", "telomerase reverse transcriptase", "epidermal growth factor receptor", "PTPRZ1-MET", and "clinical treatment".
Study Selection: Articles regarding the morphological pathology of GBM, the epidemiology of GBM, genetic alteration of GBM, and the development of treatment for GBM patients were identified, retrieved, and reviewed.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
September 2010
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
March 2009
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
December 2005
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
December 2005