Design of a highly stable and conductive electrolyte by suppressing barium copper oxide formation at the grain interfaces in Cu-doped BaCeZrDyO sintered at a low temperature (1200 °C) for SOFCs.

Proton-conducting electrolytes with high conductivity and long-term stability, achievable at low sintering temperatures, are of paramount importance. In this study, we investigate the impact of Cu doping on the sintering mechanism, electrical performance, and stability of BaCeZrDyO (BCZD) electrolyte. The morphology, composition, structure, and chemical state of BCZD electrolytes were investigated using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS).

[Not Available].

A molecular editing reaction for converting pyrrole rings into benzene rings through a sequential pathway of Diels-Alder and cheletropic reactions was developed. The nitrogen atom in a N-bridged intermediate is eliminated in the form of NO by a strain-releasing pathway, ultimately leading to the formation of substituted benzene and naphthalene derivatives.

Palladium-Catalyzed Regioselective Insertion of Carbenes into γ-C(sp)-H Bonds of Aliphatic Amines.

A migratory insertion of carbenes into distal γ-C(sp)-H bonds of aliphatic amines has been successfully developed. The synergistic interplay among a palladium catalyst, picolinamide directing group, a carefully selected base additive, and an essential ligand proved crucial in achieving high yields. These findings hold significant value for advancing the exploration of regioselective carbene insertions into nonactivated C(sp)-H bonds.

A Bibliometric Analysis of Global Research Trends in Psoriasis and Metabolic Syndrome.

Background: Psoriasis is a frequent form of chronic inflammation in dermatology that is unmistakably linked to the metabolic syndrome (MetS) and its elements. This study was to explore the current status and new developments in the global research, and the holistic landscape of this field more intuitively through bibliometric analysis of scientific output and activity.

Methods: Publications regarding psoriasis and MetS were searched and chosen from the database of the Web of Science Core Collection.

[Effect of acupotomy on the fat infiltration degree of lumbar multifidus muscle in patients with lumbar disc herniation after percutaneous transforaminal endoscopic discectomy].

Objective: To observe the effect of acupotomy on the fat infiltration degree of lumbar multifidus muscle (LMM) in patients with lumbar disc herniation after percutaneous transforaminal endoscopic discectomy (PTED).

Methods: A total of 104 patients with lumbar disc herniation treated with PTED were randomly divided into an observation group (52 cases, 3 cases dropped off) and a control group (52 cases, 4 cases dropped off). Patients of both groups received rehabilitation training of two weeks 48 h after PTED treatment.

Identification of potential key molecules and signaling pathways for psoriasis based on weighted gene co-expression network analysis.

Background: Psoriasis is a chronic inflammatory skin disease, the pathogenesis of which is more complicated and often requires long-term treatment. In particular, moderate to severe psoriasis usually requires systemic treatment. Psoriasis is also associated with many diseases, such as cardiometabolic diseases, malignant tumors, infections, and mood disorders.

Recent Research Advances in Plasma Spraying of Bulk-Like Dense Metal Coatings with Metallurgically Bonded Lamellae.

Although thermal spray metallic coatings have been widely used for materials protection from wear, corrosion and oxidation, its porous feature limits the full utilization of materials potential. Moreover, the oxidation inherent to thermal spraying in the ambient atmosphere is detrimental to interlamellar bonding formation, which further degrades the performance of thermal spray metal coatings. How to tape out the full potential of spray materials in the form of the coating is a still great challenge to thermal spray coating technology.

Plasma-Sprayed (BiO) (ErO) (WO) Electrolyte for Intermediate-Temperature Solid Oxide Fuel Cells (IT-SOFCs).

Stabilized bismuth oxide material with fluorite structure (δ-BiO) has been studied as a promising electrolyte material for intermediate temperature solid oxide fuel cells (IT-SOFCs) due to its high oxygen ion conductivity in mediate temperature. Especially, the ternary system BiO-ErO-WO is widely concerned for its high ionic conductivity and thermal stability. In this study, regarding its low melting point, the possibility to deposit dense BiO-ErO-WO ((BiO) (ErO) (WO), EWSB) electrolyte by plasma spraying was examined.

Plasma-Sprayed High-Performance (BiO)(YO) Electrolyte for Intermediate-Temperature Solid Oxide Fuel Cells (IT-SOFCs).

Rare earth element-doped bismuth oxides with the fluorite structure (δ-BiO) exhibit high oxygen ion conductivity at low temperature, which is promising electrolyte materials for intermediate-temperature solid oxide fuel cells (IT-SOFCs). However, traditional co-sintering process is not applicable to the manufacturing of IT-SOFCs using low melting point BiO-based electrolyte, while further high-temperature processing is not required for deposition BiO-based electrolytes. In this study, plasma spraying was used to examine the possibility to deposit high-performance BiO-based electrolytes without the following high-temperature process.

Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis.

Background: Psoriasis is a chronic inflammatory skin disease, affecting about 0.6% of the Chinese population. Many patients are not well controlled by conventional treatments, thus there is need for new treatment regimens.

A meta-analysis comparing confocal microscopy and dermoscopy in diagnostic accuracy of lentigo maligna.

Purpose: We aimed to summarize the sensitivity and specificity between RCM and dermoscopy in LM diagnosis.

Methods: A meta-analysis was conducted to the study. PubMed, Google Scholar, Cochrane Library, and Wiley Online Library database were searched for relevant studies.

A multimodal therapeutic approach improves the clinical outcome of auricular keloid patients.

Objective: We retrospectively studied the efficacy of personalized therapy with surgical resection plus prophylactic management of postsurgical auricular keloids by intralesional injection of betamethasone and local pressure therapy using magnets in patients with auricular keloids.

Methods: Surgical excision was performed in all patients, and surgical techniques including fusiform excision of the keloid scar, core excision of the keloid scar followed by flap repair, and scar graft were chosen.

Results: A total of 85 patients with 98 auricular keloids were eligible.

Expression profiling analysis of autophagy-related genes in perineural invasion of cutaneous squamous cell carcinoma.

The aim of the present study was to identify the potential autophagy-related genes and to explore the underlying molecular mechanisms involved in cutaneous squamous cell carcinoma of head and neck (cSCCHN) by bioinformatics analysis. The Gene Expression Omnibus (GEO) series GSE86544 was downloaded from the GEO database. The primary data was generated from cSCCHN with clinical perineural invasion (PNI) and cSCCHN without PNI, and was further analyzed in order to identify differentially expressed genes (DEGs).

Safety and efficacy of etanercept monotherapy for moderate-to-severe plaque psoriasis: A prospective 12-week follow-up study.

Etanercept has been shown to be effective for the treatment of moderate-to-severe plaque psoriasis. Since most clinical trials examined etanercept in combination with other drugs, the efficacy and safety of etanercept monotherapy for moderate-to-severe plaque psoriasis have not been well established. This prospective study enrolled 61 Chinese patients with moderate-to-severe plaque psoriasis to explore the efficacy and safety of etanercept monotherapy.

Matrix metalloproteinase 1: a better biomarker for squamous cell carcinoma by multiple microarray analyses.

Background: The present study aimed to validate MMP1 role in the development of squamous cell carcinoma (SCC) by bioinformatics methods.

Methods: Gene expression data of 10 GSE series (5 HNSCCs and 5 cSCCs) were obtained from the Gene Expression Omnibus (GEO) database and used to identify differentially expressed genes (DEGs).

Results: Higher expression of MMP1 was found rank number one in 9/10 GSE series of SCC.

Small molecule-driven directional movement enabling pin-hole free perovskite film via fast solution engineering.

Organolead trihalide perovskite materials have been widely used as light absorbers in efficient photovoltaic cells. Solution engineering is a fast and effective method to fabricate perovskite films. Here, we report a fast precipitation of a pin-hole free perovskite film by small molecule-driven directed diffusion engineering.

Rab23's genetic structure, function and related diseases: a review.

Rab23 has been proven to play a role in membrane trafficking and protein transport in eukaryotic cells. Rab23 is also a negative regulator of the Sonic hedgehog (Shh) signaling pathway in an indirect way. The nonsense mutation and loss of protein of Rab23 has been associated with neural tube defect in mice and aberrant expression in various diseases in human such as neural system, breast, visceral, and cutaneous tumor.

Nano-porous TiO2 layer using ultrafine nano-particles for the blocking layer in dye-sensitized solar cells.

A nano-porous TiO2 layer was produced by spray-deposition using ultrafine anatase nano-particles for the blocking layer for the dye-sensitized solar cells (DSCs). The microstructure and the electrochemical properties of the spray-deposited TiO2 layer were examined. The results of electrochemical properties showed that the spray-deposited TiO2 layer was capable to suppress the I3- ions diffusion to FTO substrate, reducing the electron recombination between the electrons on FTO substrate and I3- ions in electrolyte.

[Correlation between facial nerve functional evaluation and efficacy evaluation of acupuncture treatment for Bell's palsy].

Objective: To assess and grade facial nerve dysfunction according to the extent of facial paralysis in the clinical course of acupuncture treatment for Bell's palsy, and to observe the interrelationship between the grade, the efficacy and the period of treatment, as well as the effect on prognosis.

Methods: The authors employed the House-Brackmann scale, a commonly used evaluation scale for facial paralysis motor function, and set standards for eye fissure and lips. According to the improved scale, the authors assessed and graded the degree of facial paralysis in terms of facial nerve dysfunction both before and after treatment.

[Diagnosis and treatment of bone lymphangioma associated with spinal deformity in children].

Objective: To investigate the diagnosis, treatment and outcomes of bone lymphangioma associated with spinal deformity in children.

Methods: Eight cases of children with bone lymphangioma associated with spinal deformity at our hospital from 1983 to 2010 were reviewed and analyzed with the following criteria: clinical manifestations, imaging features, histopathological characteristics and therapeutic options. The outcomes of early intervention treatment were assessed.

The influence of BCR density on the differentiation of natural poly-reactive B cells begins at an early stage of B cell development.

B cell antigen receptor (BCR) density plays a role in the differentiation of immature B cells to their mature compartments; however, the exact strategy of its influence on the development of natural autoreactive B cells is still unclear. In the present study, we explored the role of BCR surface density in autoreactive B cell development by studying two lines of mice containing distinct copy numbers of an IgH transgene with V(H) derived from a poly-reactive natural antibody 3B4. Surface BCR levels were found to be related to the transgene copy number in these mice.

[Clinical analysis of 48 patients with vaginal enlarged amputation of cervix].

Objective: To evaluate the feasibility and safety of vaginal enlarged amputation of cervix to treat patients with cervical cancer of stage Ia1 and cervical intraepithelial neoplasia grade III (CIN III) who were unfit for conization surgery.

Methods: From July 2002 to May 2007, patients with cervical cancer at stage Ia1, diagnosed by pathology after loop electrosurgical excision procedure (LEEP), large area CIN III (the area of lesion>or=3/4 on colposcopy), CIN III coexisted with vaginal intraepithelial neoplasia (VAIN) in the superior segment of vagina, CIN II-III recurrence or with residual lesion, positive margin after conization of cervix, who wanted to preserve fertility and (or) corpus uteri were selected to receive vaginal enlarged amputation of cervix.

Results: Forty-eight cases including 5 with cervical cancer in stage Ia1, 38 with large area CIN III (9 with gland involvement), 2 with residual lesion and 2 with positive margin after LEEP, 1 recurrence after cold knife conization, received the procedure successfully.

Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris.

Nuclear factor kappa-beta (NF-kappaB) is a critical transcription factor modulating the expression of many genes involved in the pathogenesis of psoriasis. SUMO4 is a negative regulator of NF-kappaB in the cell-signaling pathway. Two functional polymorphisms of the NFKB1 and SUMO4 genes have been found to be associated with the risks of some autoimmune-related diseases, but no published study has investigated the role of these polymorphisms in the etiology of psoriasis in the Chinese population.

Identification of poly-reactive natural IgM antibody that recognizes late apoptotic cells and promotes phagocytosis of the cells.

Unlabelled: Natural IgM can recognize apoptotic cells, but the molecular structure and the role in macrophage phagocytosis of apoptotic cells remain unclear.

Objectives: (1) To examine the binding of previously isolated natural IgM (3B4) to apoptotic cells and its effects on phagocytosis of apoptotic cells. (2) To characterize the molecular structure of 3B4.