Preparation and evaluation of HPMC-based pirfenidone solution in vivo.

Context: Pirfenidone (PFD) has exhibited therapeutic potential in the treatment of cell proliferative disorders. The previously developed 0.5% water-based PFD eye drops by our team exhibited antiscarring effectiveness and ocular safety but with a limit of short half-life and poor bioavailability.

Preparation of 0.05% FK506 suspension eyedrops and its pharmacokinetics after topical ocular administration.

Purpose: To investigate the stability of FK506 eye suspension and its pharmacokinetics in rabbit aqueous humor, as well as its distribution in eye tissues.

Methods: Sedimentation rate, flocculation value, redispersion time, rheological study, and accelerated experiment were determined for evaluating the stability of FK506 suspension. In a single-dose pharmacokinetic study, six rabbits were instilled a 25-microL drop of 0.

[Ocular penetration and pharmacokinetics of topical voriconazole in rabbit eyes].

Objective: To investigate the penetration of topical 1% voriconazole into the cornea and aqueous humor in New Zealand white rabbits.

Methods: It was a experimental study. Forty-eight healthy rabbits were randomly divided into groups A (21 cases), B (21 cases) and C (6 cases).

[The pharmacokinetics of FK506 and its nanoparticles in aqueous humor of rabbits].

Objective: To investigate the pharmacokinetics of FK506 and its nanoparticles in aqueous humor of rabbits applied with eye drops or subconjunctiva injections.

Methods: 42 New Zealand albino rabbits were divided into 2 groups. (1) Nanoparticle solution containing 10 microg FK506 was injected into subconjunctiva or dropped on conjunctival sac of rabbits (68 eyes in 34 cases).