Publications by authors named "Cheng-ping Chang"

Background: Glove reuse poses risks, as chemicals can persist even after cleaning. Decontamination methods like thermal aeration, recommended by US OSHA, vary in effectiveness. Some studies show promising results, while others emphasize the importance of considering both permeation and tensile strength changes.

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Marked reductions in mean annual rainfall associated with climate change in Eswatini in Southern Africa have encouraged the recycling of irrigation water and the increased use of pesticides in agricultural production, raising concerns about potential ecological and health risks due to long-term exposure to pesticide residues in soil and irrigation water. This probabilistic integrated risk assessment used liquid chromatography with tandem mass spectrometry to analyze the concentrations of four commonly used agricultural pesticides (ametryn, atrazine, pendimethalin, and 2,4-dichlorophenoxyacetic acid (2,4-D)) in irrigation water and topsoil samples from farmlands in Eswatini to assess potential ecological and health risks due to exposure. The concentrations of these pesticides ranged from undetectable to 0.

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  • A COVID-19 outbreak was studied in a high-rise building with seven infected individuals, occurring in September 2021.
  • Researchers used a tracer-gas experiment and virus sequencing to track how the virus spread among the residents.
  • The findings suggest that the virus was likely transmitted vertically between apartments on different floors, rather than through horizontal interactions.
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We investigated a cluster of SARS-CoV-2 infections in a quarantine hotel in Taiwan in December 2021. The cluster involved 3 case patients who lived in nonadjacent rooms on different floors. They had no direct contact during their stay.

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  • Concerns about pesticide inhalation risks for agricultural workers in Eswatini are highlighted, especially given the widespread use of pesticides in sugar cane production, which is vital for the economy.
  • A study analyzed air samples from 76 pesticide applicators and found significant levels of four commonly used herbicides, indicating higher exposure than in previous studies.
  • Despite the use of personal protective equipment (PPE), applicators experienced high inhalation exposure, suggesting the need for better practices, including maintaining distance from one another during spraying to minimize risks.
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Two-dimensional electron systems have attracted attention as thermoelectric materials, which can directly convert waste heat into electricity. It has been theoretically predicted that thermoelectric power factor can be largely enhanced when the two-dimensional electron layer is far narrower than the de Broglie wavelength. Although many studies have been made, the effectiveness has not been experimentally clarified thus far.

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We synthesized unique one-dimensional (1D) nanorods and two-dimensional (2D) thin-films of NiO on indium-tin-oxide thin-films using a hot-filament metal-oxide vapor deposition technique. The 1D nanorods have an average width and length of ∼100 and ∼500 nm, respectively, and the densely packed 2D thin-films have an average thickness of ∼500 nm. The 1D nanorods perform as parallel units for charge storing.

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  • - This study evaluated the effectiveness of powered air-purifying respirators (PAPRs) in reducing worker exposure to indium in sputter target manufacturing plants from 2010-2012.
  • - Fifty-four workers participated, completing questionnaires and providing blood and urine samples to analyze biomarkers related to indium exposure before and after PAPRs were introduced.
  • - Results showed a 6.6% penetration rate of indium inside the respirators, with significant reductions in biomarker levels indicating decreased exposure after PAPRs were implemented, highlighting their potential for improving occupational health.
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  • The study aimed to evaluate and compare two methods for measuring volatile organic compounds (VOCs) in petrochemical factories: thermal desorption tubes and stainless steel canisters.
  • Researchers collected air samples from twelve factories in Mailiao Industrial Complex using both methods over a six-hour period, analyzing a total of 94 paired samples.
  • Results showed strong consistency for some VOCs between the methods, but statistically significant differences in measurements for others, indicating systematic errors likely due to differences in detection limits.
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Epithelial cell adhesion molecule (EpCAM) is known to be overexpressed in epithelial cancers associated with enhanced malignant potential, particularly colorectal carcinoma (CRC) and head and neck squamous cell carcinoma (HNSCC). However, it is unknown whether progression of malignance can be directly inhibited by targeting EpCAM. Here, we have generated five novel monoclonal antibodies (mAbs) against EpCAM.

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  • The four serotypes of dengue virus (DENV1-4) pose a significant global health risk, particularly due to antibody-dependent enhancement (ADE), where certain antibodies can worsen the disease by promoting viral infection.
  • Researchers generated 16 new monoclonal antibodies (mAbs) targeting DENV4 and assessed their neutralizing and enhancing activities using various laboratory tests.
  • Notably, two specific mAbs, DD11-4 and DD18-5, were found to strongly enhance DENV infection, and their epitope sites on the virus were identified, which could aid in developing safer dengue vaccines.
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Study Objectives: Sleep-disordered breathing (SDB) is associated with an increased risk of motor vehicle crashes. This study aimed to understand SDB progression and related factors among professional drivers.

Methods: A total of 524 professional male drivers from a transportation company were included in this study.

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Background: Dengue virus (DENV) is a significant public health threat in tropical and subtropical regions of the world. A therapeutic antibody against the viral envelope (E) protein represents a promising immunotherapy for disease control.

Methodology/principal Findings: We generated seventeen novel mouse monoclonal antibodies (mAbs) with high reactivity against E protein of dengue virus type 2 (DENV-2).

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This work evaluates the characteristics of short-term release of volatile and semi-volatile organic chemicals from clothing fabrics that are exposed to environmental tobacco smoke (ETS). Various fabrics were concurrently exposed to ETS in a controlled facility, and the chemicals off-gassed were sampled using solid phase micro-extraction coupled with GC/MS analysis. Toluene-reference concentration (TRC) was calculated for nine selected chemicals and compared.

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Aim Of The Study: Tetramethylammonium ion (TMA) is an emerging industrial chemical and has caused mortalities in humans. The present study was conducted to evaluate the effects of subcutaneously injected TMA on heart rate (HR), mean arterial blood pressure (MAP) and arterial blood gases (ABG) and to determine whether pretreatment using mechanical ventilation (MV) or atropine could prevent the mortality caused by TMA.

Methods: Male Wistar rats were anesthetized and catheterized in the femoral arterials for monitoring.

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Background: Overexposure to carbon disulfide (CS(2) ) has been associated with an increase in coronary heart disease, but the mechanisms mediating this effect remain unclear. We aimed to examine the relationship between CS(2) exposure and oxidative stress markers, in order to clarify the oxidative mechanisms involved in CS(2) -induced atherosclerosis.

Methods: A total of 89 workers from a viscose rayon plant were recruited for this study, and 111 workers not exposed to CS(2) served as controls.

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This study investigated the effect of NaOH on the vitrification of electroplating sludge. Ni, the major metal in the electroplating sludge, is the target for recovery in the vitrification. Sludge and encapsulation materials (dolomite, limestone, and cullet) were mixed and various amounts of NaOH were added to serve as a glass modifier and a flux.

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This study compared respirable dust and nanoparticle concentrations measured by different sampling devices at a titanium dioxide pigment factory. Respirable particle mass concentrations, nanoparticle concentrations, particle size distribution and particle metallic content were measured at different sampling locations. The sampling results of the Multi-orifice Uniform Deposit Impactor (MOUDI) showed that the particle size distribution at this titanium dioxide production factory fell in the range of 1-10 mu m.

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This paper establishes particulate exposure predictive models based on vibration measurements under various concrete drilling conditions. The whole study was conducted in an exposure chamber using a full-scale mockup of concrete drilling simulator to simulate six drilling conditions. For each drilling condition, the vibration of the three orthogonal axes (i.

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This study used a full scale mockup of a concrete drilling simulator to simulate drilling processes in an exposure chamber. Six drilling conditions were selected with rotating speeds and drill bit sizes varied from 265 to 587 rpm and 16 to 32 mm, respectively. For each drilling condition, the emitted noise power spectrums were measured and dust exposure concentrations of the fractions of the total (C(tot)), inhalable (C(inh)), thoracic (C(tho)), and respirable (C(res)) were estimated.

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Ultraviolet radiation (UVR) exposure is known to cause potential effects such as erythema in skin. For UV-induced erythema (sunburn), the action spectrum from the Commission Internationale de l'Eclairage, International Commission on Illumination (CIE) was adopted. Erythemal UV effects from UVR lamp exposure were investigated with commercial spectroradiometry devices in this research.

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This study established a comprehensive approach to monitoring UVR magnitude from Shield Metal Arc Welding (SMAW) processing and quantified the effective exposure based on measured data. The irradiances from welding UVR were calculated with biological effective parameter (Slambda) for human exposure assessment. The spectral weighting function for UVR measurement and evaluation followed the American Conference of Governmental Industrial Hygienists (ACGIH) guidelines.

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In order to speculate the physical mechanisms of contaminant leakage during sash movement and walk-bys through a laboratory fume cupboard, the complicated three-dimensional flow patterns and the real-time tracer gas leakage are studied via the laser-assisted flow visualization method and the standard gas sampling technique, respectively, over a transparent, full scale chemical fume cupboard. Through the flow visualization, the evolution of drastic changes of the flow pattern is demonstrated. The highly turbulent jet-like currents are induced by the unsteady flow motion near the cupboard face.

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Objective: In 2005, the Taiwan Institute of Occupational Safety and Health started an on-site consulting program for the medical supplies manufacturing industry, which use ethylene oxide (EO) as a sterilant, with the goal of enhancing occupational hygiene practices and controlling EO-related risks. This study presents EO exposure assessment results and examines the effectiveness of control measures.

Methods: Detailed surveys, including exposure monitoring, were conducted at 10 factories.

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Synopsis of recent research by authors named "Cheng-ping Chang"

  • - Cheng-Ping Chang's research extensively investigates health risks associated with chemical exposures, particularly in agricultural contexts, evidenced by studies on pesticide contamination and inhalation risks to agricultural workers in Eswatini.
  • - His work also delves into the efficacy of protective equipment against hazardous materials, including evaluating rubber glove materials and powered air-purifying respirators for worker safety in industrial settings.
  • - Additionally, Chang explores infectious disease transmission, notably through investigations of COVID-19 clusters which highlight unconventional routes of transmission in residential and quarantine settings in Taiwan.