Publications by authors named "Cheng-hui Zhou"
Disulfidptosis is a novel form of cell death that is distinguishable from established programmed cell death pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and oxeiptosis. This process is characterized by the rapid depletion of nicotinamide adenine dinucleotide phosphate (NADPH) in cells and high expression of solute carrier family 7 member 11 (SLC7A11) during glucose starvation, resulting in abnormal cystine accumulation, which subsequently induces andabnormal disulfide bond formation in actin cytoskeleton proteins, culminating in actin network collapse and disulfidptosis. This review aimed to summarize the underlying mechanisms, influencing factors, comparisons with traditional cell death pathways, associations with related diseases, application prospects, and future research directions related to disulfidptosis.
View Article and Find Full Text PDFAim: Determining whether intraoperative cerebral oximetry monitoring-guided intervention reduces the risk of postoperative cognitive dysfunction remains controversial. The objective of this study was to conduct an up-to-date meta-analysis to comprehensively assess the effects of regional cerebral oxygen saturation (rSO) monitoring-guided intervention on cognitive outcomes after cardiac surgery.
Methods: PubMed, EMBASE, Ovid, and Cochrane Library databases were systematically searched using the related keywords for cardiac surgical randomized-controlled trials (RCTs) published from their inception to July 31, 2021.
The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives.
Signal Transduct Target Ther
July 2021
Article Synopsis
- Pancreatic cancer is becoming more common and is often diagnosed late, leading to a poor outlook for patients, with treatments not being very effective due to the disease's complexity.
- Recent research has advanced our understanding of the biology and genetics of pancreatic cancer, allowing for better classification and potential treatment options.
- The review covers the role of biological features, metabolic changes, and the tumor microenvironment in cancer development, along with emerging biomarkers, treatment responses, and challenges in developing new therapies.
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide, but there is a shortage of effective biomarkers for its diagnosis.
Aim: To explore blood exosomal micro ribonucleic acids (miRNAs) as potential biomarkers for HCC diagnosis.
Results: The principal component analysis suggested that daily alcohol consumption could alter the blood exosomal miRNA profiles of hepatitis B virus positive non-HCC patients through miR-3168 and miR-223-3p.
Background:: Calcium regulatory proteins-L-type Ca channels (LTCCs), ryanodine receptor 2 (RyR2), and Na/Ca exchanger isoform 1 (NCX1) have been recognized as important protective mechanisms during myocardial ischemia-reperfusion injury (I/RI). Both sevoflurane postconditioning (SevoPoC) and delayed remote ischemic preconditioning (DRIPC) have been shown to protect the heart against I/RI. In this study, we aimed to compare the effects of SevoPoC and DRIPC on the expression of the three calcium regulatory proteins in an isolated rat heart model.
View Article and Find Full Text PDFAim: Sevoflurane postconditioning (SpostC) has been shown to protect the heart from ischemia-reperfusion (I/R) injury. In this study, we examined whether SpostC affected autophagic flux in myocardial tissues that contributed to its cardioprotective effects in rats following acute I/R injury.
Methods: SD rats underwent 30 min of left anterior descending coronary artery ligation followed by 120 min of reperfusion.
Background: The association between fish consumption and heart failure (HF) incidence is inconsistent.
Methods: We performed a systematic search of Pubmed and Embase (from 1953 to June 2012) using key words related to fish and HF. Studies with at least three categories of fish consumption reporting both relative risk (RR) and corresponding 95% confidence interval (CI) for HF incidence were included.