Metabolic Profiling Revealed Prediction Biomarkers for Infantile Hemangioma in Umbilical Cord Blood Sera: A Prospective Study.

Infantile hemangioma (IH), the most common benign tumor in infancy, mostly arises and has rapid growth before 3 months of age. Because irreversible skin changes occur in the early proliferative stage, early medical treatment is essential to reduce the permanent sequelae caused by IH. Yet there are still no early screening biomarkers for IH before its visible emergence.

Aesthetic outcome of intralesional injection of lauromacrogol as a single-agent treatment for uncomplicated infantile hemangiomas: A long-term follow-up study.

Infantile hemangiomas (IH) are at risk of incomplete regression with remnant permanent sequelae, ranging from passive waiting for spontaneous regression to active systemic administration. The application of traditional therapy involving injection of a sclerosing agent is limited due to the difficulty in achieving cosmetic improvement. This study aimed to explore a new injection method that could not only promote tumor regression but also achieve cosmetic improvement.

Removal of dissolved sulfides in aqueous solution by activated sludge: mechanism and characteristics.

Activated sludge recycling has been developed as a novel technique to directly prevent volatile sulfides emission from wastewater influents. In this study, mechanisms and characteristics of dissolved sulfides removal in aqueous solution by activated sludge were investigated. When DO content in water was 0.

Angiogenin: a potential serum marker of infantile hemangioma revealed by cDNA microarray analysis.

Background: Hemangiomas are characterized by rapid growth but slow regression. Prognosis and treatment urgently require the identification of serum markers to determine the proliferative potential of hemangiomas.

Methods: Using four pairs of tissue from the proliferative and involution stages of the same hemangiomas, the authors performed cDNA microarray experiments to study differential expression of genes between proliferative hemangiomas and involuting hemangiomas.

[Transposition of orbital fat and orbicularis muscle flap over the orbital rim for correction of lower eyelid pouches complicated with lacrimal groove deformity].

Objective: To introduce the experience in the treatment of lower eyelid pouches orbital rim.

Methods: An incision was made along the margin of lower eyelid and dissection was performed under the orbicularis muscle to expose the orbital septum and periosteum of lower orbital rim. The fat released from orbital septum was transposed just below the lower orbital rim and fixed on the periosteum.

[Clinical application of imiquimod for the treatment of infantile hemangiomas].

Objective: To explore the clinical application of imiquimod for the treatment of infantile hemangiomas (IH).

Methods: 320 children with IH, including 250 superficial cases, 20 deep cases, and 50 mixed cases, were treated with 5% imiquimod cream every other day for 16 weeks. The clinical efficacy and side effects were evaluated at one year of age.

Retrospective analysis of facial paralysis caused by ethanol sclerotherapy for facial venous malformation.

Background: Absolute ethanol sclerotherapy provides a reliable treatment for facial venous malformation, although facial nerve injury may occur after sclerotherapy. This study is a retrospective review of facial nerve dysfunction after sclerotherapy.

Methods: A total of 91 patients with facial venous malformations accepted 288 ethanol sclerotherapy sessions.

[A prospective study of propranolol as first-line treatment for problematic infantile hemangioma in China].

Objective: To prospectively assess the efficacy and safety or propranolol as a first-line treatment for problematic infantile haemangioma in China.

Methods: From Mar. 2009 to Feb.

Reconstruction of the cheek after large port-wine stain lesion resection.

Background: A laser is commonly used in treatment of port-wine stain (PWS). Although observable lightening of the stains can be achieved, complete removal is rare. A significant proportion of lesions are resistant to laser treatment, including hypertrophic lesions and scars developed after improper (unsuccessful) treatments.

[A three-dimension in vitro model for angiogenesis of hemangioma].

Objective: To create a three dimension (3D) in vitro model for angiogenesis of hemangioma.

Method: The fragment of hemangioma specimen was embedded in fibrin gel to set up the three-dimension (3D) in vitro model for angiogenesis of hemangioma.

Result: In the model, microvessels grew out from the tissue fragments at the 2nd to 3rd day after culture, and at the 8th to 9th day a compact network of microvessels come into being, then tending to be stationary.