The study aimed to assess how mild hypothermia during the ischemic phase affects protein levels of IL-1beta and MCP-1 in the brains of rats after a focused period of restricted blood flow.
Eighty male Wistar rats were assigned to either a normal temperature group or a mild hypothermia group, and both groups underwent procedures to induce and measure the effects of ischemia and reperfusion over varying times.
Results showed that IL-1beta levels remained unchanged in both groups, while MCP-1 levels increased in the normothermic group after six hours of reperfusion, indicating the lack of significant impact of mild hypothermia on IL-1beta but potential implications for MCP-1 levels.