Publications by authors named "Cheng-gang Zhu"
Article Synopsis
- Lipoprotein(a) [Lp(a)] is recognized as a potential predictor for atherosclerotic cardiovascular disease (ASCVD), with a study involving 9944 Chinese patients revealing its association with increased cardiovascular event risk based on current risk stratification guidelines.
- Patients were categorized into very-high-risk (VHR) and non-VHR subgroups, with Lp(a) plasma levels influencing the prevalence of cardiovascular events (CVEs) observed over an average follow-up of 38.5 months.
- The results indicated that higher Lp(a) levels correlate with a significant increase in CVE risk, especially in the VHR subgroup, with adjusted hazard ratios showing a 2.18 times higher risk in the highest Lp
Article Synopsis
- This study looked at a substance called Endothelin-1 (ET-1) and how it might be linked to heart problems in people with diabetes and other blood sugar issues.
- Researchers followed nearly 8,000 patients with heart disease over a few years to see if higher levels of ET-1 could predict serious heart events, like heart attacks.
- They found that patients with diabetes or prediabetes and higher ET-1 levels were more likely to have these heart problems, suggesting ET-1 could help doctors predict risks in these patients.
Objectives: To evaluate the predictive value of fasting plasma glucose (FPG) for in-hospital mortality in patients with acute myocardial infarction (AMI) with different glucose metabolism status.
Methods: We selected 5,308 participants with AMI from the prospective, nationwide, multicenter CAMI registry, of which 2,081 were diabetic and 3,227 were nondiabetic. Patients were divided into high FPG and low FPG groups according to the optimal cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts, respectively.
Article Synopsis
- - The study investigates the clinical significance of new indices, TyAG and TyAG-BMI, which incorporate estimated average glucose into existing measures of insulin resistance (TyG and TyG-BMI) in patients with atherosclerotic cardiovascular disease (ASCVD).
- - Conducted on nearly 10,000 Chinese patients, the study analyzed cardiovascular events over 38.5 months and found that higher values of TyAG and TyAG-BMI correlated with increased cardiovascular risk factors and event rates.
- - Results indicated that TyAG and TyAG-BMI might provide improved risk prediction for cardiovascular events compared to the traditional indices, with TyAG-BMI showing the strongest predictive capability.
Article Synopsis
- - The study investigates how stress-related glycemic indicators (like admission blood glucose, stress-hyperglycemia ratio, and glycemic gap) affect cardiovascular mortality outcomes in patients over 80 years old who experienced acute myocardial infarction (AMI).
- - Researchers analyzed data from 933 elderly patients and found that higher levels of these glycemic indicators were associated with significantly increased risks of both short-term (30 days) and long-term cardiovascular mortality.
- - The results reveal a J-shaped effect for admission blood glucose and a U-shaped effect for the other two indicators, highlighting their importance in assessing the health of older adults following AMI.
Aim: No data are currently available regarding the association between Lp(a) and the cardiovascular outcomes in patients with coronary artery disease (CAD) according to their family history (FHx) of CAD. This study aimed to evaluate the significance of Lp(a) in predicting major adverse cardiovascular events (MACEs) in patients with chronic coronary syndrome (CCS) with or without FHx.
Methods: A total of 6056 patients with CCS were enrolled.
Article Synopsis
- * A study involved 8,263 patients with stable coronary artery disease, categorizing them by Lp(a) and Fib levels to monitor ischemic stroke occurrences over a median follow-up of 37.7 months.
- * Results showed that patients with high levels of both Lp(a) and Fib had the highest incidence of ischemic stroke, suggesting that assessing both factors together could better predict stroke risk compared to evaluating them separately.
Article Synopsis
- LDL-TG (low-density lipoprotein-triglyceride) is a new lipid marker found to be connected to cardiovascular events (CVEs) in patients with chronic coronary syndrome (CCS) undergoing PCI (percutaneous coronary intervention).
- A study involving 4,415 patients investigated the association of LDL-TG and hs-CRP (high-sensitivity C-reactive protein) levels on the risk of CVEs over 7 years, revealing that higher LDL-TG concentrations correlated with more CVEs, particularly in patients with elevated hs-CRP levels.
- The findings suggest that measuring both LDL-TG and hs-CRP can help predict cardiovascular risks more effectively in patients treated with PCI, especially those with higher
Background: Although experimental studies have demonstrated the protective role of total bilirubin (TBil) in cardiovascular diseases, several previous clinical observations are controversial. More importantly, no data are currently available regarding the relation of TBil to major adverse cardiovascular events (MACE) in patients with previous myocardial infarction (MI).
Objectives: This study sought to explore the association between TBil and long-term clinical outcomes in patients with previous MI.
Objectives: To assess the correlation between triglyceride glucose (TyG) index and in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI).
Methods: A total of 2190 patients with STEMI who underwent primary angiography within 12 h from symptom onset were selected from the prospective, nationwide, multicenter CAMI registry. TyG index was calculated with the formula: Ln [fasting triglycerides (mmol/L) × fasting glucose (mmol/L)/2].
Background: Transradial artery (TRA) access for percutaneous coronary intervention (PCI) was associated with lower risks of major bleeding and vascular complications compared to transfemoral artery access. Use of large-bore ( 7-Fr) guiding catheters through TRA approach increased the likelihood of radial artery occlusion (RAO). This study aimed to investigate whether use of the thin-walled 7-Fr Glidesheath Slender, allowing PCI with large-caliber guiding catheters, is superior to standard 7-Fr Cordis sheath with respect to periprocedural RAO within 24 hours after transradial coronary intervention (TRI) in complex lesions.
View Article and Find Full Text PDFBackground: Hypertension is a known risk factor for cardiovascular disease; however, its impact on clinical outcomes in patients with heterozygous familial hypercholesterolemia (HeFH) is unclear. Hence, we aimed to investigate the effects of hypertension on severity of coronary artery atherosclerosis and cardiovascular outcomes in patients with HeFH.
Methods: A total of 480 patients with clinical or molecular diagnosis of definite or probable familial hypercholesterolemia according to Dutch Lipid Clinic Network criteria (DLCN score ≥6) were included in the study.
Background: The positive relationship between metabolic healthy obesity (MHO) and cardiovascular risk has been under debate in recent years. Previously, strong evidence supported the causal role of increased plasma lipoprotein(a) [Lp(a)] levels in cardiovascular disease (CVD). The current study aimed to investigate the different associations of Lp(a) and cardiovascular events (CVEs) in patients with coronary artery disease (CAD) and different metabolic phenotypes.
View Article and Find Full Text PDFBackground: Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors. This study sought to evaluate the combined impact of RC, Lp(a), and inflammation on prognosis of statin-treated patients with chronic coronary syndrome (CCS), which has not been investigated.
Methods: A total of 6839 patients with CCS were consecutively enrolled.
Background: Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary heart disease (CHD). However, the mechanism underlying SORBS2 involvement in the development of hypercholesterolemia remains unknown.
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- A study involving 9,944 patients with atherosclerotic cardiovascular disease (ASCVD) aimed to understand the variability in recurrent events among them, particularly in a Chinese population.
- Researchers found that as the number of major ASCVD events increased, patients exhibited more high-risk conditions and a higher prevalence of severe coronary lesions.
- The presence of diabetes was linked to worse outcomes in patients with multiple events, highlighting the importance of tailored risk assessments rather than a one-size-fits-all approach.
Background: Patients with previous myocardial infarction (MI) have a poor prognosis and stratification for recurrent major adverse cardiovascular events (MACE) among these patients is of considerable interest. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) are considered to be potential cardiovascular risk factors, but less is known about their prognostic importance in post-MI patients. This study aimed to evaluate the prognostic value of NT-proBNP and hs-CRP alone or together in patients who reported a prior MI.
View Article and Find Full Text PDFBackground: The risk of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) can be easily evaluated by noninvasive scoring systems, of which the NAFLD fibrosis score (NFS) is the most commonly used. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a new predictor of cardiovascular events, has been reported to be associated with cardiovascular outcomes and NAFLD. However, the relationship of NFS with PCSK9 and their prognostic abilities in cardiovascular risks are unknown.
View Article and Find Full Text PDFBackground: Lipoprotein (a) [Lp(a)] is a causal risk factor for cardiovascular diseases, while its role in vascular calcification has not been well-established. Here, we investigated an association of Lp(a) with vascular calcification using population-based and in vitro study designs.
Methods: A total of 2806 patients who received coronary computed tomography were enrolled to assess the correlation of Lp(a) with the severity of coronary artery calcification (CAC).
Background: Although the presence of physical signs [tendon xanthomas and/or corneal arcus (TX/CA)], are associated with the risk of coronary artery disease in patients with heterozygous familial hypercholesterolemia (HeFH), their relationship with genotypes and clinical characteristics has not been fully determined. This study aimed to examine the association of TX/CA with genetic mutation, lipid- and inflammation-related markers, the severity of coronary stenosis or calcification, and cardiovascular events (CVEs) in patients with HeFH.
Methods: LDLR, APOB, and PCSK9 genes were screened in 523 HeFH patients, and patients with TX/CA (n = 50) were 1:4 propensity score-matched to patients without TX/CA (n = 200) to adjust for age and sex.
Article Synopsis
- PCSK9 is linked to atherosclerosis and thrombotic processes, prompting a study on its relationship with coagulation and cardiovascular events among patients with chest pain.
- The study included 2,293 patients, measuring PCSK9 levels and various coagulation indicators, finding that higher PCSK9 levels correlate with lower prothrombin time (PT) and activated partial thromboplastin time (APTT).
- The results indicated that high PCSK9 and low PT levels are significant risk factors for major adverse cardiovascular events (MACEs), suggesting that combining these factors can help better predict cardiovascular risks in patients.
Background: Continuous refinement of atherosclerotic cardiovascular disease (ASCVD) stratification has raised the definition of very-high-risk (VHR) recently, which has been underutilized in China. We aimed to identify patients at VHR and evaluate their performances in a Chinese population.
Methods: A total of 9944 patients with ASCVD was continuously enrolled.
Background: It has been demonstrated that patients with type 2 diabetes mellitus (DM) is associated with increased cardiovascular risk. However, little is known regarding the long-term prognosis in diabetic patients who experience mild-to-intermediate coronary artery stenosis (CAS). This study was to assess the clinical outcomes of diabetic patients with different severity of CAS.
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- A recent study suggests that metabolic-associated fatty liver disease (MAFLD) may be a more appropriate term than nonalcoholic fatty liver disease (NAFLD) and examines its effects on major cardiovascular events in chronic coronary syndrome patients.
- The study followed 3,306 patients with MAFLD and found a higher occurrence of major adverse cardiac events (MACEs) in this group compared to matched controls without MAFLD over an average period of about 55 months.
- The results indicate that MAFLD significantly increases the risk of MACEs, even when considering NAFLD criteria, highlighting the clinical importance of using MAFLD for better patient assessment.
Background And Aims: The association of triglyceride-rich lipoprotein-cholesterol (TRL-C) with recurrent cardiovascular events (RCVEs) has not been studied. Moreover, whether inflammation can affect TRL-C-associated cardiovascular risk is unknown. This study sought to examine the association between TRL-C and RCVEs, and whether this relationship is modulated by systemic inflammation in statin-treated patients with coronary artery disease (CAD) and nearly normal triglyceride.
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