Synopsis of recent research by authors named "Cheng-chin Wu"
- Cheng-Chin Wu's recent research primarily focuses on the genetic and molecular mechanisms underlying autoimmune diseases such as Sjögren's syndrome, systemic lupus erythematosus (SLE), rheumatoid arthritis, and connective tissue diseases, particularly investigating the roles of human leukocyte antigen (HLA) genotypes and gene polymorphisms in disease development.
- Wu has reported significant findings indicating that specific HLA-DR genotypes, particularly HLA-DR8, are associated with an increased risk of primary Sjögren's syndrome in the Taiwanese population, and that various genetic and epigenetic alterations contribute to the pathogenesis and clinical manifestations of SLE and rheumatoid arthritis.
- The research also delves into the role of macrophages in connective tissue disease-associated interstitial lung disease, highlighting the potential for targeted therapeutic strategies, and emphasizes the impact of aberrant methylation patterns and inflammasome activation in the progression of autoimmune conditions.
