Dauricine alleviates cognitive impairment in Alzheimer's disease mice induced by D-galactose and AlCl via the Ca/CaM pathway.

Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly. Dysregulation of intracellular Ca homeostasis plays a critical role in the pathological development of AD. Dauricine (DAU) is a bisbenzylisoquinoline alkaloid isolated from Menispermum dauricum DC.

Total alkaloids from the seed embryo of Gaertn. improve cognitive impairment in APP/PS1 mice and protect Aβ-damaged PC12 cells.

The seed embryo of Gaertn. is a famous traditional Chinese medicine and food which is considered conducive to the prevention of Alzheimer's disease (AD). In this study, the effect and mechanism of TASENN (total alkaloids from the seed embryo of Gaertn.

Protective effects of Liensinine, Isoliensinine, and Neferine on PC12 cells injured by amyloid-β.

Excessive accumulation of amyloid-β (Aβ) is the leading cause of Alzheimer's disease (AD). Liensinine, Isoliensinine, and Neferine are main alkaloids in lotus seed embryos. In this paper, the protective effects of Liensinine, Isoliensinine, and Neferine on Aβ -injured PC12 cells were studied.

An Improved Sensing Method of a Robotic Ultrasound System for Real-Time Force and Angle Calibration.

An ultrasonic examination is a clinically universal and safe examination method, and with the development of telemedicine and precision medicine, the robotic ultrasound system (RUS) integrated with a robotic arm and ultrasound imaging system receives increasing attention. As the RUS requires precision and reproducibility, it is important to monitor the real-time calibration of the RUS during examination, especially the angle of the probe for image detection and its force on the surface. Additionally, to speed up the integration of the RUS and the current medical ultrasound system (US), the current RUSs mostly use a self-designed fixture to connect the probe to the arm.

[Health assessment on aquatic ecosystem in Liaohe River of Liaoning Province].

Based on the investigation of the hydrology, water quality, periphytic algae, and habitat conditions of 20 hydrologic sections in the Tieling, Shenyang, and Panjin reaches of Liaohe River from June to August 2009, the indicators and their weights for the health assessment of aquatic ecosystem in the River were screened and determined by the method of principal component analysis, and the River's health assessment indicator system and health assessment standard system were constructed. The modified gray correlative degree method was also used to evaluate the aquatic ecosystem health condition at six sections of the River. Among the sections evaluated, three of them had a fair health level, two were worse or worst, and only one reached sub-health degree, suggesting that the aquatic ecosystem in the River was seriously degraded.

[Tongxinluo improves vascular endothelial function in patients with type 2 diabetes].

Objective: To investigate the effects of Tongxinluo on vascular endothelial function in patients with type 2 diabetes.

Methods: A total of 80 patients with type 2 diabetes were recruited and divided into two groups: Tongxinluo therapy group (n = 40) and conventional therapy group (n = 40). Plasma levels of NO, ET, 6-keto-PGF1alpha and TXB2 and diastolic functions of humeral arteries (measured by high-resolution ultrasound) were measured at baseline and 4 weeks later.

[Efficacy and safety of Fufang Biejia Ruangan tablet in patients with chronic hepatitis B complicated with hepatic fibrosis].

Objective: To study the clinical therapeutic effects and safety of Fufang Biejia Ruangan tablet (FBRt) in patients with chronic hepatitis B complicated with hepatic fibrosis.

Methods: Totally 420 patients were randomly divided into two groups, FBRt group (300 cases) were treated with Fufang Biejia Ruangan tablets and control group (120 cases) were treated with He Luo Shu Gan capsule, the patients in both groups were treated for 6 months.

Results: The cure rate and total effective rate of FBRt group were significantly higher than those of control group (55.

[The impact of elevated serum creatinine on the prognosis of acute myocardial infarction].

Objective: To evaluate the clinical features and outcomes in patients suffering from acute myocardial infarction combined with elevated serum creatinine.

Methods: We enrolled 340 consecutive patients suffering from acute myocardial infarction admitted into our hospital from 2003.2.