Publications by authors named "Cheng-Zhong Zheng"
Rationale: Respiratory distress syndrome (RDS) refers to the symptoms of progressive dyspnea and respiratory failure in newborns shortly after birth. The clinical and genetic characteristics of patients with neonatal RDS have not been extensively reported.
Patient Concerns: A infant was in critical condition with repeated paroxysmal blood oxygen decline.
Article Synopsis
- The study investigates the clinical features, treatment, and outcomes of COVID-19 and viral pneumonia in children during the pandemic, noting that COVID-19 infections were less common in children compared to adults.
- A total of 64 children with COVID-19 and 284 children with pneumonia from other viruses were compared in terms of their clinical and epidemiological data, using various statistical tests to analyze the differences.
- Results showed that COVID-19 affected older children more, had less severe cases compared to other viral pneumonias, and they experienced fewer symptoms like high fever, highlighting differences in the disease presentation between the two groups.
[Expert consensus on the prevention and treatment of drowning in children].
Zhongguo Dang Dai Er Ke Za Zhi
January 2021
Drowning is a leading cause of accidental injury in children and has a great impact on family and society. The prevention and treatment of drowning is of great importance for reducing mortality rate. This consensus reviews the literature on the epidemiology, rescue, resuscitation, and acute clinical management and prevention of drowning.
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- The study aimed to explore how adipose-derived stem cells (ADSC) and non-methylated CpG-oligodeoxynucleotides (CpG-ODN) affect regulatory T cells in young mice with food allergies, along with their immune system effects.
- 40 BALB/c mice were divided into four groups (control, allergic, ADSC treatment, and CpG-ODN treatment), and an allergy model was created using ovalbumin (OVA) to assess the effectiveness of treatments.
- Results showed that both the ADSC and CpG-ODN treatment groups had reduced allergy symptoms and lower OVA-IgE levels compared to the allergic group but still showed higher levels than the control
Article Synopsis
- The study investigates how certain genetic variations in pulmonary surfactant proteins impact serum levels and the likelihood of respiratory distress syndrome (RDS) in preterm infants.
- Researchers analyzed 100 preterm infants with RDS and 120 without, using genetic testing and serum level quantification of specific surfactant proteins.
- Findings reveal that specific genetic polymorphisms in SP-A and SP-B are linked to a higher risk of RDS, with reduced SP-A levels potentially serving as biomarkers for the condition.
[Immunoregulatory effect of adipose-derived stem cell transplantation in young mouse model of food allergy].
Zhongguo Dang Dai Er Ke Za Zhi
July 2016
Objective: To investigate the immunoregulatory effect of adipose-derived stem cell (ADSC) transplantation by intraperitoneal injection in food-allergic young mice before and after ovalbumin (OVA) sensitization.
Methods: Thirty-two 3-week-old female Balb/c mice were randomly divided into control, allergic model, ADSC treatment, and ADSC prevention groups (n=8 each). A young mouse model of food allergy was established by OVA sensitization via intraperitoneal injection.
[Effect of non-methylated CpG-ODN on serum TGF-β and immune regulation in ovalbumin-sensitized young mice].
Zhongguo Dang Dai Er Ke Za Zhi
August 2015
Objective: To explore the effect of non-methylated cytosine-phosphate-guanine oligodeoxynucleotides (CpG-ODN) on serum transforming growth factor (TGF)-β and immune regulation in ovalbumin (OVA)-sensitized young mice.
Methods: Thirty female BALB/c mice (2-3 weeks old) were randomly divided into control, model, and CpG-ODN intervention groups. A young mouse model of food allergy was established by OVA sensitization.