Inhibition of Long non-coding RNA zinc finger antisense 1 improves functional recovery and angiogenesis after focal cerebral ischemia via microRNA-144-5p/fibroblast growth factor 7 axis.

Long non-coding RNA zinc finger antisense 1 (ZFAS1) has been probed in cerebral ischemia, while the regulatory mechanism of ZFAS1 in focal cerebral ischemia (FCI) via binding to microRNA (miR)-144-5p remains rarely explored. This study aims to decipher the function of ZFAS1 on FCI via sponging miR-144-5p to modulate fibroblast growth factor 7 (FGF7). The focal cerebral ischemia rat model was established by occlusion of the middle cerebral artery (MCAO) Lentivirus vectors altering ZFAS1, miR-144-5p or FGF7 expression were injected into rats before MCAO.

NBPF9 Gene May Be Involved in Congenital Hypopituitarism: A Whole-Genome Study of a Boy with Pituitary Stalk Interruption Syndrome and His Family.

Pituitary stalk interruption syndrome (PSIS) is a rare congenital defect manifesting as various degrees of anterior pituitary hormone deficiency. Scattered familial cases have been found, revealing some genetic variants. However, most of the previous research studies involved an affected sibling, and the gene spectra of the patients' entire family have rarely been reported.

Obesity-associated secondary hypogonadism in young and middle-aged men in Guangzhou: A single-centre cross-sectional study.

Aim: Male obesity-associated secondary hypogonadism (MOSH) is becoming a public health issue. We aimed to know MOSH among young and middle-aged men in our hospital, to analyse their sex hormones and other index, and to determine leptin as a risk factor for MOSH.

Methods: In total, 258 men (ages ranging from 20 to 60, mean 38 ± 15) were enrolled in this study, and 242 of these men had their complete data, body mass index (BMI), waist circumference and sex hormones retrospectively investigated.

Normal height and novel mutations in growth hormone deficiency adults with pituitary stalk interruption syndrome.

Objective: Pituitary stalk interruption syndrome (PSIS) is a rare congenital disease which results in hypopituitarism. Patients with PSIS often exhibit short stature due to their deficiency of growth hormone (GH).

Case Presentation: Here, we present two rare cases of adults males with PSIS, in which the patients were of normal height and did not take any GH supplements.

Multi-genic pattern found in rare type of hypopituitarism: a whole-exome sequencing study of Han Chinese with pituitary stalk interruption syndrome.

Pituitary stalk interruption syndrome (PSIS) is a rare type of hypopituitarism manifesting various degrees of pituitary hormone deficiency. Although mutations have been identified in some familial cases, the underpinning mechanisms of sporadic patients with PSIS who are in a vast majority remain elusive, necessitating a comprehensive study using systemic approaches. We postulate that other genetic mechanisms may be responsible for the sporadic PSIS.

Clinical Features of Pituitary Stalk Interruption Syndrome in 114 Cases.

Objective To analyze the clinical characteristics of pituitary stalk interruption syndrome(PSIS). Methods The clinical data including clinical manifestations,laboratory tests,and imaging findings of 114 PSIS patients in our hospital were retrospectively analyzed. Results Of these 114 PSIS patients,102 cases (89.

[Purification efficiency of four different ecotypes of wetland plants on eutrophic water body].

Four wetland plant species (Acorus calamus, Typha orientalis, Lemna minor, Ceratophyllum demersum) were grown to compare the purification efficiency of wetland plant species alone and in combination on two eutrophic water bodies, high concentration sewage (influent) and low concentration sewage (effluent) in a wastewater treatment plant. The results showed that the concentration of total nitrogen (TN), total phosphorus (TP) and chemical oxygen demand (COD) decreased sharply at the beginning of the test, but this decreasing trend slowed down in the late phase. The wetland plants could remove TN, TP and COD from wastewater effectively, but the degree of purification was different among different wetland plant species and among different combinations of these species.

Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy.

Recently, investigation of bacterial-based tumor therapy has regained focus due to progress in molecular, cellular, and microbial biology. Many bacteria such as Salmonella, Listeria, Escherichia, and Clostridium have proved to have tumor targeting and in some cases even tumor-destroying phenotypes. Furthermore, bacterial clinical treatments for cancer have been improved by combination with other therapeutic methods such as chemotherapeutic drugs and radioactive agents.

Two-dimensional nanosheets of MoS2: a promising material with high dielectric properties and microwave absorption performance.

In this study, few-layered MoS2 nanosheets (MoS2-NS) were obtained via the top-down exfoliation method from bulk MoS2 (MoS2-Bulk), and the dielectric properties and microwave absorption performance of MoS2-NS were first reported. The dimension-dependent dielectric properties and microwave absorption performance of MoS2 were investigated by presenting a comparative study between MoS2-NS and MoS2-Bulk. Our results show that the imaginary permittivity (ε'') of MoS2-NS/wax is twice as large as that of MoS2-Bulk/wax.

[High-fat diet induces pulmonary fibrosis in rats and inhibitory effects of N-acetylcysteine].

Objective: To explore the relation between high-fat diet and pulmonary fibrosis and the inhibition of N-acetylcysteine (NAC) on lung tissue in rats.

Methods: Thirty Sprague Dawley (SD) male rats were randomly divided into control group (n = 10) on a quantitative control Lieber-DeCarli liquid diet, a high-fat diet group (n = 10) on a high fat-diet Lieber-DeCarli liquid diet and NAC group (n = 10) on NAC 300 mg×kg(-1)×d(-1). All rats were sacrificed 8 weeks later.

The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice.

Secoisolariciresinol (SECO) is a natural lignan-type phytoestrogen constituent mainly found in flaxseed. It can be metabolized in vivo to mammalian lignans of enterodiol and enterolactone, which have been proven to be effective in relieving menopausal syndrome. Depression is one of the most common symptoms of menopausal syndrome, and is currently treated with estrogen replacement and antidepressant therapy.

[Project about how to deal with the interrupted test of environmental test for medical electrical equipment].

The environmental test for medical electrical equipment may be interrupted by power cut or the equipment broken and so on. For the purpose of standard and valid testing, this paper puts forward a project about how to deal with the interrupted disposal of environmental test for medical electrical equipment. The project aims at the environmental requirements and test methods for GB/T 14710--93.