Publications by authors named "Cheng-Yong Yu"
Article Synopsis
- - T2DM is a progressive condition characterized by insulin resistance and declining β-cell function, with research indicating that microRNA (miRNA) plays a significant role in treatment.
- - The study investigates the specific miRNA-125b-5p's effects on pancreatic β-cell function and insulin sensitivity in T2DM mice, alongside the involvement of Dapper1 (DACT1) and the JNK signaling pathway.
- - Results show that T2DM mice had lower β-cell function and insulin sensitivity, linked to reduced miR-125b-5p and increased DACT1 and JNK levels; enhancing miR-125b-5p can improve insulin sensitivity by inhibiting the JNK pathway and D
STAT3, a member of signal transducers and activators of transcription (STATs) originally discovered as mediators in cytokine signaling pathways, plays an active role in oncogenesis. However, the function of STAT3 in signaling multistage carcinogenesis, especially in transformation of tumor-promotion sensitive epithelial cells has not been elucidated. The present study demonstrates that STAT3 is activated in interleukin-6 induced transformation in mouse skin epithelial cells.
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