Diagnostic utility of HLA-B*5801 screening in severe allopurinol hypersensitivity syndrome: an updated systematic review and meta-analysis.

Background: Despite many studies suggesting an association between human leukocyte antigen (HLA)-B*5801 and allopurinol-induced toxic epidermal necrolysis (TEN) and Stevens-Johnsons syndrome (SJS), the evidence of association in different populations and the degree of association remain uncertain.

Methods: The primary analysis was based on population-control studies. Data were pooled by means of a random-effects model, and sensitivity, specificity, positive likelihood ratios (LR+), negative likelihood ratios (LR-), diagnostic odds ratios (DOR), and areas under summary receiver operating characteristic (SROC) curves (AUC) were calculated.

Traps in regioregular poly(3-hexylthiophene) and its blend with [6,6]-phenyl-C61-butyric acid methyl ester for polymer solar cells.

Thermally stimulated current (TSC) technique is used to characterize traps in the regioregular poly(3-hexylthiophene) (rr-P3HT) and its blend with [6,6]-phenyl-C61-butyric acid methyl ester (PCBM). A hole trap in bulk rr-P3HT and an interfacial hole trap located at indium tin oxide (ITO)/rr-P3HT interface are revealed from the TSC measurement. Besides, molecular oxygen (O2) can form a deep electron trap with an onset of detrapping temperature at 225 K in rr-P3HT, in which O2 is located at the main chain region and the detrapping process is induced by chain motions under elevated temperature.