Artemisia argyi extracts overcome lapatinib resistance via enhancing TMPRSS2 activation in HER2-positive breast cancer.

Breast cancer stands as the predominant malignancy and primary cause of cancer-related mortality among females globally. Approximately 25% of breast cancers exhibit HER2 overexpression, imparting a more aggressive tumor phenotype and correlating with poor prognoses. Patients with metastatic breast cancer receiving HER2 tyrosine kinase inhibitors (HER2 TKIs), such as Lapatinib, develop acquired resistance within a year, posing a critical challenge in managing this disease.

Investigation of the impact of Globo-H expression on the progression of gastric cancer.

Globo-H (GH), a globo-series glycosphingolipid antigen that is synthesized by key enzymes β1,3-galactosyltransferase V (β3GalT5), fucosyltransferase (FUT) 1 and 2, is highly expressed on a variety of epithelial cancers rendering it a promising target for cancer immunotherapy. GH-targeting antibody-drug conjugate has been demonstrated an excellent tumor growth inhibition potency in animal models across multiple cancer types including Gastric cancer (GC). This study aims to further investigate the GH roles in GC.

Diffusion tensor imaging with cerebrospinal fluid suppression and signal-to-noise preservation using acquisition combining fluid-attenuated inversion recovery and conventional imaging: comparison of fiber tracking.

Objective: To propose an acquisition scheme suitable for fiber tractography without cerebrospinal fluid contamination while retaining high signal-to-noise ratio.

Materials And Methods: Diffusion tensor imaging (DTI) data at b=0 and 1000 s/mm(2) were acquired using conventional spin-echo echo-planar imaging (TR/TE=4000/69, NEX=4, scan time 2:14) plus one additional fluid-attenuated inversion recovery (FLAIR) b=0 set obtained at TI=2200, TR=6000, and NEX=6 (scan time 1:36). The FLAIR images were intensity-adjusted to match the conventional b=0 images according to the white matter signals.