Publications by authors named "Cheng-Xiang Yi"
Article Synopsis
- Research identifies the presence of the fungus Aspergillus sydowii within tumors of lung adenocarcinoma (LUAD) patients, highlighting the significance of the intratumor mycobiome in cancer development.
- Experiments on lung cancer mouse models show that A. sydowii accelerates tumor growth by activating certain immune cells (MDSCs) through the IL-1β signaling pathway, leading to weakened immune responses.
- The study indicates that higher levels of A. sydowii in human tumors correlate with immune suppression and worse outcomes for patients, suggesting potential for targeting this fungus to improve treatment for LUAD.
The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a specific pattern of microbiota, sharing many key pathological and physiological characteristics with the intestinal tract.
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