Effects of vitamin D supplementation on oxidative stress and antioxidant enzyme after strenuous endurance exercise in healthy young men: a double-blind, placebo-controlled trial.

Vitamin D exhibits strong antioxidant properties. However, its effect on oxidative stress after strenuous endurance exercise remains unclear. Therefore, we investigated the effects of vitamin D supplementation on strenuous endurance-exercise-induced oxidative stress.

Immunologic, Anti-Inflammatory, and Anti-Muscle Damage Profile of Supplemented Vitamin D in Healthy Adults on Strenuous Endurance Exercise.

Reportedly, strenuous endurance exercise can depress the immune system and induce inflammation and muscle damage. Therefore, this double-blinded, matched-pair study aimed to investigate the impact of vitamin D supplementation on immune response (leukocyte, neutrophil, lymphocyte, CD4, CD8, CD19, and CD56 counts), inflammatory profile (TNF-α and IL-6), muscle damage (CK and LDH levels), as well as aerobic capacity after strenuous endurance exercise in 18 healthy men taking 5000 IU of vitamin D ( = 9) or placebo ( = 9) daily for 4 weeks. Total and differential blood leukocyte counts, levels of cytokines, and muscle damage biomarkers were determined before, immediately after, and 2, 4, and 24 h after exercise.