Publications by authors named "Cheng-Rong Lu"
Aim: The phosphorylation of histone H2AX, a novel tumor suppressor protein, is involved in regulation of cancer cell apoptosis. The aim of this study was to examine whether H2AX phosphorylation was required for resveratrol-induced apoptosis of human chronic myelogenous leukemia (CML) cells in vitro.
Methods: K562 cells were tested.
[Influence of calcineurin on apoptosis of pre-B lymphocytes and the leukemia cells derived from pre-B lymphocytes].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2014
Article Synopsis
- This study compares calcineurin expression in mouse Pre-B cell lines (S9) and leukemia tumor cell lines (S4C2) to understand its role in cell apoptosis.
- Using techniques like quantitative PCR and Western blot, researchers found that S4C2 cells had significantly higher calcineurin levels, correlating with increased resistance to apoptosis.
- The findings suggest calcineurin contributes to preventing apoptosis in leukemia cells, and that cyclosporine A enhances apoptotic effects in these cells, especially when combined with the drug imatinib.
[Detection of the expression of NK ligands in acute leukemia cell lines by real-time PCR].
Zhonghua Xue Ye Xue Za Zhi
January 2013
Article Synopsis
- - The study aimed to analyze the expression profiles of 23 natural killer (NK) ligands in various acute leukemia cell lines and to compare differences between acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
- - Using quantitative real-time PCR, the researchers found significant differences in the expression of four NK ligands, with ULBP-2 being more expressed in ALL, while CD48, PVR, and DR4 were higher in AML.
- - The findings suggest that ULBP-2, CD48, PVR, and DR4 could be key factors in how ALL and AML develop, highlighting their potential as targets for future diagnosis and treatment strategies.
Aim: Histone H2AX is a novel tumor suppressor and its phosphorylation at the C terminus (Ser139 and Tyr142) is required for tumor cell apoptosis. The aim of the present study was to elucidate the mechanisms underlying imatinib-induced C-terminal phosphorylation of H2AX in chronic myelogenous leukemia cells in vitro.
Methods: BCR-ABL-positive K562 cells were used.
[Expression of NKG2D and NKG2A with their ligands MHC-I A/B and HLA-E in acute leukemia patients and its significance].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2011
This study was aimed to explore the difference of NK cell receptor NKG2D and NKG2A expression on NK cells and CD3(+) T cells and their ligand MHC-I A/B (major histocompatibility complex class I-related chains A/B) and HLA-E expression in leukemia cells, as well as its immunological significance. Flow cytometry was used to detect the killing rate of NK92 cells to 8 leukemia cell lines, and the expression of NKG2D and NKG2A on NK cells and CD3(+) T cells as well as their ligand MHC-I A/B and HLA-E expression on leukemia cells. The results indicated that the NK92 showed different killing activity to different leukemia cell lines.
View Article and Find Full Text PDF[Study of rating scale of mentally prisoner's competency to serve a sentence].
Fa Yi Xue Za Zhi
August 2005
Article Synopsis
- - The study aimed to develop a tool called the Competency to Serve a Sentence Rating Scale to assess the mental competency of prisoners in accordance with Chinese law.
- - The researchers combined knowledge from Chinese criminal law and forensic psychiatry to create and validate this instrument, which showed high reliability and good correlation with expert assessments.
- - Ultimately, the study concluded that this rating scale is a feasible instrument for determining whether prisoners can serve their sentences based on their mental competence.
Article Synopsis
- The study investigates the factors affecting the competency of mentally ill prisoners to serve their sentences, aiming to establish a quantitative basis for assessing this competency.
- Researchers developed a questionnaire to evaluate the legal and psychological capacity of prisoners, testing the hypothesis that those in a treatment ward are incompetent, while those in a rehabilitation unit are competent to serve their sentences.
- Findings highlight significant differences between the psychiatric and legal aspects of mentally ill prisoners, concluding that psychiatric symptoms impair their competency and suggest they should be moved from prison to a hospital for appropriate care.
In the molecule of the title compound, C16H13BrO, the two benzene rings are rotated in opposite directions with respect to the central C-C=C-C part of the molecule. The phenone O atom deviates from the least-squares plane of the molecule by 0.300 (3) A.
View Article and Find Full Text PDFMolecular packing analyses were carried out on 15 crystal data sets of chloro-substituted Schiff bases, including that of the title compound, C15H15ClN2. C-H..
View Article and Find Full Text PDF