Publications by authors named "Cheng-Qin Liang"

Esculetin is a coumarin compound with anticancer, antioxidant, and anti-inflammatory activities. In this study, we synthesized an esculetin derivative, 6,7-bis(Pentyloxy)-2H-Chromen-2-One (BPCO), through etherification. BPCO inhibited the proliferation of HepG2 cells in a dose- and time-dependent manner.

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Two new quinazolinone alkaloids, benzomalvin F (), and quinadoline C (), along with four known quinazolinones (-), were isolated from cultures of the wetland-soil-derived fungus from the Huixian wetland in Guilin. Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and IR spectra. In addition, the anti-inflammatory results showed that compounds , , , and had significant inhibitory effects on NO production in RAW264.

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Four previously undescribed phloroglucinols, including three pairs of enantiomers, (±)-rhodotomentodimer F, (±)-rhodotomentodimer G, and (±)-rhodotomentomonomer E, and one phloroglucinol-sesquiterpene meroterpenoid, rhodotomentodione E, together with one previously reported congener, (±)-rhodomyrtosone A, were obtained from the leaves of Rhodomyrtus tomentosa. The structures including absolute configurations of previously undescribed isolates were elucidated by extensive spectroscopic analysis (HRESIMS and NMR), ECD calculations, and single-crystal X-ray diffraction. (±)-Rhodotomentodimer F is a rare phloroglucinol derivative conjugated by a β-triketone moiety and an unprecedented resorcinol unit via the formation of a rare bis-furan ring system, whereas (±)-rhodotomentomonomer E shares a rearranged pentacyclic scaffold.

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Article Synopsis
  • A novel dammarane triterpenoid saponin, Cypaliuruside F, was isolated from leaves and examined for its antitumor effects on HepG2 liver cancer cells using various assays like MTT and flow cytometry.
  • The study involved network pharmacology and molecular docking to identify key targets of Cypaliuruside F in fighting hepatocellular carcinoma (HCC).
  • Results showed that Cypaliuruside F hinders HepG2 cell growth by triggering apoptosis and cell cycle arrest, primarily by downregulating mTOR, STAT3, and Bcl-2 while enhancing Bax expression.
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Alzheimer's diseases (AD) and other infectious diseases caused by drug-resistance bacteria have posed a serious threat to human lives and global health. With the aim to search for human acetylcholinesterase (hAChE) inhibitors and antibacterial agents from medicinal plants, 16 phloroglucinol oligomers, including two new phloroglucinol monomers (1a and 1b), four new phloroglucinol dimers (3a, 3b, 4b, and 5a), six new phloroglucinol trimers (6a, 6b, 7a, 7b, 8a, and 8b), and two naturally occurring phloroglucinol monomers (2a and 2b), along with two known congeners (4a and 5b), were purified from the leaves of tropic Rhodomyrtus tomentosa. The structures and absolute configurations of these new isolates were unequivocally established by comprehensive analyses of their spectroscopic data (NMR and HRESIMS), ECD calculation, and single crystal X-ray diffraction.

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Previous in vivo and in vitro studies revealed that esculetin (Fig. 1) has anti-hepatitis B virus (anti-HBV) activity as well as a protective effect on liver damage caused by duck hepatitis B virus. We designed and synthesized a series of esculetin derivatives, introduced side chains containing various amino groups into site 7 of the parent structure, and synthesized C-4 and C-8 substituted derivatives with the goal of investigating their anti-HBV activities.

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A new oleanane-type triterpenoid saponin, 21, 22-di--angeloyl-15, 16, 28-trihydroxyolean-12-ene 3---L-rhamnopyranosyl-(1→3)--D-xylopyranosyl-(1→3)--D-glucopyranoside (), together with five known compounds (), were isolated from . Their structures were elucidated based on spectroscopic methods, including extensive NMR and MS spectra. Compound showed potential inhibitory activity on α-glucosidase with the IC values of 185.

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Two undescribed dammarane triterpenoid saponins, cypaliurusides O and P ( and ), were isolated from the ethanol extracts of the leaves of . Bioactivity assay results showed that compound has potential cytotoxic activities against selected human cancer cell lines , with IC values ranging from 14.55 ± 0.

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Undescribed phloroglucinol derivatives, rhotomensones A-G, and a known derivative rhodomyrtosone B, were isolated from the leaves of Rhodomyrtus tomentosa. Rhotomensones A-D and G have unreported structural characteristics, in which rhotomensone A substitutes a benzene ring, rhotomensones B-D are bonded with a 2-methylbutanoyl group, and rhotomensone G has two fewer carbons. The structures of these compounds were determined by NMR spectroscopy, circular dichroism (CD) spectroscopy and X-ray crystallography.

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Although clinically approved hepatitis B virus (HBV) polymerase inhibitors (lamivudine-3TC, entecavir, etc.) serve as effective therapeutics, the virus can easily generate resistance to them. Therefore, the treatment of HBV infection remains a public health problem.

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Article Synopsis
  • Diabetes mellitus, linked to chronic inflammation, impacts millions globally, with Cyclocarya paliurus leaves traditionally used as a diabetes remedy, prompting further research into its active components.
  • Twenty dammarane saponins were identified in C. paliurus leaves through bioassay-guided separation, including eleven new compounds, with structures determined by spectral analysis.
  • Notably, compounds 1 and 2 showed strong α-glucosidase inhibitory and anti-inflammatory effects, suggesting that dammarane saponins could be vital in developing new antidiabetic treatments.
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Thirteen undescribed dammarane triterpenoid saponins (cypaliurusides A-M), including eleven seco-dammarane type triterpenoids, were isolated from Cyclocarya paliurus. Each of these compounds has the unique feature of having a monosaccharide attached to C-11, rather than C-12, compared to the same type of saponins found in this plant. The structures of them were determined by comprehensive analysis of 1D, 2D NMR and HRESIMS data.

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A decoction of Plumeria rubra flowers has been used traditionally for the treatment of diabetes in China and Mexico. Chemical investigations on the bioactive constituents of these flowers led to the isolation of 30 compounds, including the four new compounds, one iridoiod (1), two triterpenoids (4, 5), and a long-chain δ-lactone (16). In addition, 26 known compounds (2, 3, 6-15, 17-30) are also reported.

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Article Synopsis
  • Coumarins, which are found in various plants, possess several pharmacological properties, including antiviral effects.
  • This study isolated a specific coumarin, esculetin, identified through spectroscopy, and tested its anti-hepatitis B virus (HBV) activity in both lab cell lines and infected ducklings.
  • Results showed that esculetin significantly reduced HBV antigen expression and DNA levels in vitro, and lowered several viral markers in vivo, indicating its potential as a future antiviral drug.
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  • Two new compounds, cyclopalosides A (1) and B (2), were discovered in the leaves of the Cyclocarya paliurus tree through a series of chromatography techniques.
  • Their chemical structures were determined using detailed spectroscopic analysis, revealing them as tetralone glycosides that include a caffeoyl group.
  • The antioxidant properties of cyclopaloside A (1) were tested, showing its effectiveness in scavenging hydroxyl, superoxide anion, and DPPH radicals.
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Five caffeoyl phenylethanoid glycosides, including two new ones linderruelliosides A (1) and B (2), were isolated from the leaves and stems of Lindernia ruellioides. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all these compounds were tested for their anti-HBV activity.

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Eleven triterpene acids including 10 new compounds (kadcoccinic acids A-J, 1-10) were isolated from the stems of Kadsura coccinea. Except for 10, these compounds feature a rearranged lanostane skeleton with a 6/6/5/6 tetracyclic ring system, and compounds 1 and 2 are the first examples of 2,3-seco-6/6/5/6-fused tetracyclic triterpenoids. Their structures were established primarily by spectroscopic and spectrometric methods.

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Three new triterpenoids, kadcotriones A-C (1-3), together with the biogenetically related lanostane-type triterpenoid (4), were isolated from Kadsura coccinea. Compound 1 features a 12,14β-dimethyl 6/6/6-fused tricyclic skeleton, while 2 and 3 are characterized by a 6/6/5-ring system. Their structures were determined by NMR and electronic circular dichroism spectroscopic methods.

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  • Two new triterpenoids, schisphendilactone A and B, were discovered from the stems of Schisandra sphenanthera, alongside three known compounds.
  • The structures of these compounds were analyzed using spectroscopic methods, with schisphendilactone A's configuration determined through single-crystal X-ray diffraction.
  • Compound 2 showed moderate effectiveness against SW480 cancer cells, while compound 5 demonstrated strong anti-HIV-1 activity, with an EC50 of 0.52 μg/ml and a high therapeutic index of 117.12.
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Six new lignans, schisphenlignans F-K (1-6), together with ten known ones, were isolated from the leaves and stems of Schisandra sphenanthera. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR, MS and CD spectra. In addition, some compounds were tested for their acute activity on insulin sensitivity in 3T3-L1 differentiated adipocytes and anti-HIV-1 activity.

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Three new phenolic compounds, yunnanensins A-C (1-3), together with fourteen known ones (4-17), were isolated from the leaves and stems of Parakmeria yunnanensis. The structures of new compounds were established on the basis of extensive spectroscopic analyses. Several compounds showed weak anti-HIV-1 activity.

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Article Synopsis
  • Five new dibenzocyclooctadiene lignans named schisphenlignans A-E were discovered from the stems of Schisandra sphenanthera, alongside eight previously known lignans.
  • The structural details of these new compounds were determined using NMR, MS, and circular dichroism spectroscopy techniques.
  • Lab tests on the isolates indicated that they did not significantly improve insulin sensitivity in adipocyte cells when administered at a concentration of 10 µM.
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  • Two new triterpenoid epimers, kadcoccitones A and B, along with a related compound called kadcoccitone C, were extracted from the plant Kadsura coccinea.
  • The compounds have a unique structure, featuring a complex tetracyclic ring system and a side chain.
  • Kadcoccitones A and C demonstrated anti-HIV-1 activity, with effective concentrations (EC50) of 47.91 and 32.66 μg/mL, indicating potential for further research in HIV treatment.
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Neolaxiflorin A (1), an unprecedented ent-kaurane diterpenoid with a bicyclo[3.1.0]hexane unit, and its seco-derivative, neolaxiflorin B (2), along with two known compounds 3 and 4 were isolated from the leaves of Isodon eriocalyx var.

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Objective: To study the chemical constituents of Rubus parvifoliu.

Methods: The constituents were isolated by column chromatography and their structures were elucidated through spectroscopic analysis such as 1H-NMR, 13C-NMR, FT-IR, et al.

Results: Seven compounds were isolated from the roots of Rubus parvifolius L.

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