Changed ventral striatum structural covariance and grey matter volume in depression during a one-year follow-up.

Empirical findings suggest reduced cortico-striatal structural connectivity in patients with major depressive disorder (MDD). However, the relationship between the abnormal structural covariance and one-year outcome of first-episode drug-naive patients has not been evaluated. This longitudinal study aimed to identify specific changes of ventral striatum-related brain structural covariance and grey matter volume in forty-two first-episode patients with major depression disorder compared with thirty-seven healthy controls at the baseline and the one-year follow-up conditions.

Targeting colorectal cancer with Herba Patriniae and Coix seed: Network pharmacology, molecular docking, and validation.

Background: Herba Patriniae and Coix seed (HC) constitute a widely utilized drug combination in the clinical management of colorectal cancer (CRC) that is known for its diuretic, anti-inflammatory, and swelling-reducing properties. Although its efficacy has been demonstrated in a clinical setting, the active compounds and their mechanisms of action in CRC treatment remain to be fully elucidated.

Aim: To identify the active, CRC-targeting components of HC and to elucidate the mechanisms of action involved.

Laeviganoids A-T, -Clerodane-Type Diterpenoids from .

Laeviganoids A-T (-), 20 new -clerodane-type diterpenoids featuring a 2-furanone (-) or a furan (-) ring, as well as six analogues (-), were isolated from the roots of . Their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallographic studies. Compounds -, , -, and could influence the anti-inflammatory protumoral phenotype of macrophages.

Transformation from polycythemia vera to acute promyelocytic leukemia: Case report and literature review.

Introduction: Transformation from chronic myeloproliferative neoplasm to acute leukemia is a feature of myeloproliferative neoplasm; however, the rate is not high. Transformation to acute promyelocytic leukemia is rare. Here, we report a case of transformation of polycythemia vera to acute promyelocytic leukemia and describe a process of clonal evolution that has not yet been reported.

Antimicrobial abietane-type diterpenoids from Torreya grandis.

Twelve undescribed abietane-type diterpenoids, along with ten known analogues were isolated from the twigs and leaves of Torreya grandis var. merrillii Hu. Their structures were characterized by spectroscopic data analyses, single-crystal X-ray diffraction, and ECD spectra.