Publications by authors named "Cheng-Kang Zhang"

Article Synopsis
  • Bioremediation of Cd (cadmium) contaminated environments can be enhanced by using plant-growth-promoting bacteria (PGPB), such as Burkholderia contaminans ZCC, which was isolated from mining soil and shows high resistance to cadmium.
  • The genomic analysis revealed that B. contaminans ZCC has unique heavy metal resistance traits due to the presence of specific genes on plasmids, allowing it to tolerate cadmium and other metals more effectively than other strains.
  • Additionally, B. contaminans ZCC displays beneficial traits for plant growth, like promoting root development and nutrient availability, and can help soybean plants grow in soils with high cadmium levels, making it a potential tool for bioremediation efforts.
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Context: Mice deficient in prokineticin 2(PROK2) and prokineticin receptor2 (PROKR2) exhibit variable olfactory bulb dysgenesis and GnRH neuronal migration defects reminiscent of human GnRH deficiency.

Objectives: We aimed to screen a large cohort of patients with Kallmann syndrome (KS) and normosmic idiopathic hypogonadotropic hypogonadism (IHH) for mutations in PROK2/PROKR2, evaluate their prevalence, define the genotype/phenotype relationship, and assess the functionality of these mutant alleles in vitro.

Design: Sequencing of the PROK2 and PROKR2 genes was performed in 170 KS patients and 154 nIHH.

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