Publications by authors named "Cheng-Hui Xue"
[Expression of Key Enzymes in Glucose Metabolism in Chronic Mountain Sickness and Its Correlation with Phenotype].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2023
Article Synopsis
- The study investigates the role of key enzymes in glucose metabolism and glucose transporters in the bone marrow of patients with chronic mountain sickness (CMS) to understand the cause of erythrocytosis (increased red blood cell production).
- It involved comparing 20 CMS patients with a control group and analyzing the mRNA and protein expressions of specific enzymes and transporters using various biochemical methods.
- Results showed that CMS patients had higher levels of certain proteins related to glucose metabolism, particularly HK2, GLUT1, and GLUT2, which correlated positively with hemoglobin levels, suggesting a shift towards increased glycolysis to meet energy demands.