Publications by authors named "Cheng-Hui Ren"
Relationship between intestinal microbial dysbiosis and primary liver cancer.
Hepatobiliary Pancreat Dis Int
April 2019
Background: Intestinal microbial dysbiosis is involved in liver disease pathogenesis. However, its role in primary liver cancer (PLC), particularly in hepatocarcinogenesis remains unclear. The present study aimed to study the changes in intestinal flora at various stages of PLC and clarify the relationship between intestinal microbes and PLC.
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- Researchers found that RTVP1 (GLIPR1) is targeted by p53 and has tumor suppressor functions, leading to a search for related genes.
- They identified a gene cluster on human chromosome 12q21 that includes hRTVP-1 and two GLIPR1-like genes (GLIPR1L1 and GLIPR1L2), along with corresponding genes in mice.
- GLIPR1L1 is specific to testis, while GLIPR1L2 is found in several tissues; all three genes are p53 targets, indicating potential similarities in their biological functions.
Previously it has been reported that caveolin-1 (cav-1) has antiapoptotic activities in prostate cancer cells and functions downstream of androgenic stimulation. In this study, we demonstrate that cav-1 overexpression significantly reduced thapsigargin (Tg)-stimulated apoptosis. Examination of the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling cascade revealed higher activities of PDK1 and Akt but not PI3-K in cav-1-stimulated cells compared to control cells.
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