An Yb(OTf)₃-Mediated Indirect Activation Strategy for the Stereoselective Synthesis of α-Sialosides from 2-Fluorosialyl Donors.

Most of chemical sialylation reactions are conducted at extremely low temperatures to achieve the formation of challenging sialic acid linkages with high stereoselectivities. Performing chemical sialylation at room temperature independent of enzymatic methods represents an effective approach, particularly significant in biological and biochemical research. Our study aims to develop a convenient method of providing α-sialyl glycosides.