Cadophorin C, a new cyclic heptapeptide isolated from a mangrove-derived fungus sp. GXIMD 03101.

One new cyclic heptapeptide, cadophorin C (), and one known analogue cadophorin B () were isolated from the mangrove-derived fungus sp. GXIMD 03101 from the mangrove  L. The chemical structure of was elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS, and the known compound was identified by comparing the data with literature values.

Millmerranones G, a meroterpene isolated from a mangrove-derived fungus sp. GXIMD 03004.

One new meroterpene derivative, millmerranones G (), and three known analogues (-) were identified from the mangrove-derived fungus sp. GXIMD 03004, which was isolated from the leaves of mangrove L. collected from Beibu Gulf in China.

Mauritone A, a new polyketide from a fungal-bacterial symbiont GXIMD 04541/ GXIMD 04532.

A new polyketide, mauritone A () with six known polyketides curvulone B (), curvularin (), 12-oxocurvularin (), (10,15)-10,11-dehydrocurvularin (), (11,15)-11-hydroxycurvularin (), and (11,15)-11-hydroxycurvularin () were isolated from the fungal-bacterial symbiont GXIMD 04541/ GXIMD 04532 derived from . Their structures were elucidated by extensive spectral analysis. All compounds (-) were evaluated for their anti-inflammatory effects.

Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus GXIMD00544.

A pair of atropisomers secofumitremorgins C () and D (), together with fifteen known alkaloids (), were isolated from a saltern-derived fungus GXIMD00544. The structures of atropisomers and were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds and displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane sp.

Carneusones A-F, Benzophenone Derivatives from Sponge-Derived Fungus GXIMD00543.

Six benzophenone derivatives, carneusones A-F (-), along with seven known compounds (-) were isolated from a strain of sponge-derived marine fungus GXIMD00543. Their chemical structures were elucidated by detailed spectroscopic data and quantum chemical calculations. Compounds , , and exhibited moderate anti-inflammatory activity on NO secretion using lipopolysaccharide (LPS)-induced RAW 264.

Sonneralignan A, a new lignan from the fruit of mangrove .

A new lignan, sonneralignan A (), along with two known lignan compounds, (+)-lariciresinol-9---D-glucopyranoside () and (-)isolariciresinol-9---D-glucopyranoside () were isolated from the n-butanol extract of the mangrove fruit. The structures of the compounds were elucidated on the basis of extensive spectral analysis. The evaluation of activity showed that compound exhibited significant anti-aging activity, which extended the mean lifespan of by up to 19.

Penicixanthene E, a new xanthene isolated from a mangrove-derived fungus Penicillium sp.

One new xanthene derivative, named penicixanthene E (1), together with one known compound 2, was isolated from the EtOAc extract of the endophytic fungus Penicillium sp. GXIMD 03101, which was identified from the mangrove Acanthus ilicifolius L. collected in the South China Sea.

Sonneradon A Extends Lifespan of by Modulating Mitochondrial and IIS Signaling Pathways.

Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove , showed remarkable antiaging activity. However, the role of SDA in antiaging remains unclear.

Two new benzophenones isolated from a mangrove-derived fungus Penicillium sp.

One new benzophenone derivative, named penibenzophenone C (1), and a new benzophenone natural product, neamed penibenzophenone D (2), together with two known compounds (3, 4) were isolated from the EtOAc extract of the endophytic fungus Penicillium sp. isolated from the mangrove Acanthus ilicifolius L. collected in the South China Sea.

Marinoid J, a phenylglycoside from fruit, ameliorates cognitive impairment in rat vascular dementia: a quantitative iTRAQ proteomic study.

Context: Fruit of (Forsk.) Vierh. (Acanthaceae) is used as a Chinese herb.

Cytotoxic benzopyranone and xanthone derivatives from a coral symbiotic fungus GXIMD 02502.

Coral-derived microorganisms have been historically proven to be prolific sources of bioactive secondary metabolites. Twelve benzopyranone and/or xanthone derivatives, including a new benzopyranone with an uncommon carboxyl group at C-8, coniochaetone K (), were obtained from the Beibu Gulf-derived coral symbiotic fungus GXIMD 02502. Their structures were determined by extensive spectroscopic data interpretation and comparison with literature values.

HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus C2F17.

Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6--methyl-chaetoglobosin Q (), were isolated from the coral-associated fungus C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations.

Sesquiterpenoids and meroterpenoids from a mangrove derived fungus sp. SCSIO 41011.

One new sesquiterpenoid, 1-methoxypestabacillin B (), along with one known sesquiterpenoid () and six known chrodrimanin-type meroterpenoids (‒) were obtained from the solid cultures of a mangrove endophytic fungus sp. SCSIO 41011. Their structures including the absolute configuration at C-6 of compound , were determined by extensive spectroscopic analyses and ECD calculations.

Nocardioides kandeliae sp. nov., an endophytic actinomycete isolated from leaves of Kandelia candel.

A Gram-stain-positive, aerobic, non-spore-forming, atrichous and short rod-shaped endophytic actinomycete, designated strain BGMRC 2075, was isolated from the leaves of Kandelia candel, and was subjected to polyphasic characterization to unravel its taxonomic position. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain BGMRC 2075 belongs to the genus Nocardioides ,showing the highest 16S rRNA gene sequence similarity to Nocardioides aestuarii JC2056 (96.1 %), Nocardioides agariphilus MSL-28 (95.

Nocardioides sonneratiae sp. nov., an endophytic actinomycete isolated from a branch of Sonneratia apetala.

A Gram-staining-positive, aerobic non-spore-forming and short-rod-shaped endophytic actinomycete was isolated from a branch of Sonneratia apetala, designated strain BGMRC0092T and investigated in detail data to determine its taxonomic position. On the basis of the 16S rRNA gene sequence analysis, the results of the phylogenetic analyses indicated that BGMRC0092T was most closely related to Nocardioides alpinus Cr7-14T (96.9 %), Nocardioides oleivorans DSM16090T (96.

Two New Secondary Metabolites from Tephrosia purpurea.

Further investigation of Tephrosia purpurea led to the isolation of a new prenylated flavone, isoglabratephrin B (1) and a new 1,2-ethanedione benzofuran derivative, purpdione B (2). The structures of the new isolates were elucidated on the basis of extensive spectroscopic analysis.

National and Gender Measurement Invariance of the Utrecht-Management of Identity Commitments Scale (U-MICS): A 10-Nation Study With University Students.

The purpose of this study was to examine the psychometric properties of the Utrecht-Management of Identity Commitments Scale (U-MICS), a self-report measure aimed at assessing identity processes of commitment, in-depth exploration, and reconsideration of commitment. We tested its factor structure in university students from a large array of cultural contexts, including 10 nations located in Europe (i.e.

An update on 2,5-diketopiperazines from marine organisms.

2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014.

New antioxidative secondary metabolites from the fruits of a Beibu Gulf mangrove, Avicennia marina.

Further chemical investigation of the fruits of the mangrove, Avicennia marina, afforded three new phenylethyl glycosides, marinoids J-L (1-3), and a new cinnamoyl glycoside, marinoid M (4). The structures of isolates were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related secondary metabolites. The antioxidant activity of the isolates was evaluated using the cellular antioxidant assay (CAA), and compounds 1-4 showed antioxidant activities, with EC50 values ranging from 23.

Four new Jacaranone analogs from the fruits of a Beibu Gulf mangrove Avicennia marina.

Four new jacaranone analogs, marinoids F-I (1-4), were isolated from the fruits of a Beibu Gulf mangrove Avicennia marina. The structures were elucidated based on analysis of spectroscopic data. Marinoids F and G are shown to be diastereoisomers of chlorocornoside, a new halogen containing marine secondary metabolite.