Publications by authors named "Cheng-Gong Li"
[Application Advance of Flow Cytometry in the CAR-T Cell Therapy--Review].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2020
Article Synopsis
- - CAR-T cells are engineered immune cells that target and kill tumors by recognizing specific antigens, making them effective against certain types of blood and solid cancers.
- - The preparation of CAR-T cells involves several steps: isolating and purifying T cells, activating and modifying them with genes, amplifying their numbers, and ensuring quality before they are infused back into the patient.
- - Recent advancements in flow cytometry have enhanced CAR-T therapy by improving pre-treatment screening, in vitro production, and post-transfusion monitoring, thus optimizing the overall effectiveness of the treatment.
Article Synopsis
- - The study explores how the immune system changes in patients with acute myeloid leukemia (AML) during development and treatment, aiming to improve prognosis predictions and clinical decisions.
- - Blood samples from 79 AML patients and 24 healthy individuals were analyzed to assess immune cell function, revealing significant defects in T and NK cells, while B-cell function stayed normal.
- - Key findings indicate that immune cell exhaustion and dysfunction are linked to worse patient outcomes, suggesting that noninvasive immune testing could help predict treatment responses and relapse risks.
Background: Recent years have witnessed the rapid evolution of therapies in chronic-phase chronic myeloid leukemia (CP-CML). To assess the efficacy and tolerability of all reported front-line treatments for patients with newly diagnosed CML, a multiple-treatments meta-analysis was performed, which accounted for both direct and indirect comparisons among those treatments.
Methods: Primary outcomes were the percentage of patients achieving major molecular response (MMR) and complete cytogenetic response (CCyR) within 12 months.
Aberrant miR-155 expression has been reported in various types of hematologic malignancies. However, the prognostic and clinicopathological value of miR-155 remains unclear. Here, we performed this systemic review and meta-analysis to comprehensively evaluate the prognostic and clinicopathological significance of miR-155 expression in hematologic malignancies.
View Article and Find Full Text PDFFour new species of Psechrus are described from Yunnan Province: P. changminae sp. nov.
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