Jatrophane Diterpenoids with Kv1.3 Ion Channel Inhibitory Effects from .

Chemical investigation of bioactive components from the whole plant of resulted in the isolation and identification of 17 new jatrophane diterpenoids, namely, heliojatrone D () and helioscopids A-P (-), along with 11 known analogues (-). The structural elucidation of the new diterpenoids was achieved by the comprehensive analysis of HRESIMS, NMR, and X-ray crystallographic data, as well as using electronic circular dichroism. Structurally, heliojatone D () is the fourth natural diterpenoid with a rare bicyclo[8.

A new bile acid from the traditional chinese medicine shedan.

A new bile acid tauro-16-hydroxy-12-sulfate-5-cholenoic acid (), along with six known ones (), was isolated from the snake bile. Its planar structure and relative configuration were elucidated based on extensive spectroscopic analyses. Moreover, compound showed inhibitory effect on NO production in RAW 264.