Publications by authors named "Cheng-Gang Zhao"
Article Synopsis
- 5-Fluorouracil (5-FU) is a common chemotherapy drug for colorectal cancer but causes side effects like severe diarrhea and intestinal damage, linked to increased senescent cells.
- Oleanolic acid (OA), a compound from food fungi and plants, shows potential in reducing these 5-FU-induced side effects by decreasing senescence markers and inflammatory responses in both cell models and mice.
- This study highlights OA's ability to enhance the cancer-fighting effects of 5-FU while lowering its toxicity, suggesting a promising new approach to colorectal cancer treatment.
