Publications by authors named "Cheng-Cong Chen"
Article Synopsis
- Researchers investigated the expression of FAP-derived CXCL1 in nasopharyngeal carcinoma (NPC) to identify its potential as a biomarker for predicting distant metastasis and its relationship with PD-L1 expression.
- The study involved 345 patients and revealed a CXCL1_FAP phenotype in cancer-associated fibroblasts (CAFs) that effectively categorized patients into low and high-risk groups for metastasis based on their survival outcomes.
- The findings suggest that the CXCL1_FAP phenotype serves as an independent prognostic factor and may enhance the effectiveness of anti-PD-1/PD-L1 immunotherapy in advanced NPC.
Background: This study sought to examine the expression and mutation status of fibroblast growth factor receptor 3 (FGFR3) in non-small cell lung cancer (NSCLC) tissues and explore the prognostic potential of FGFR3 in NSCLC.
Methods: Immunohistochemistry (IHC) was used to evaluate the FGFR3 protein expression of 116 NSCLC tissues. Sanger sequencing was used to examine the mutation status of exons 7, 10, and 15 in FGFR3.