Publications by authors named "Cheng-Chung Wu"

Article Synopsis
  • Endoscopic ultrasound (EUS) is being evaluated for its effectiveness in predicting tumor stage (T-stage) before surgery for gastric adenocarcinoma, specifically to determine suitable treatment options like endoscopic therapy or neoadjuvant therapy.
  • A retrospective study at Taichung Veterans General Hospital included patients who underwent gastrectomy after preoperative EUS, revealing that EUS had moderate accuracy, especially being highly effective in predicting T1-stage tumors (85.23% accuracy), but less so for more advanced stages.
  • The study concluded that while EUS is reliable for identifying T1-stage tumors appropriate for endoscopic treatment, it needs to be supplemented with additional methods for accurately predicting more advanced stages (T3 and above).
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Background: Bowel gangrene represents a major fatal event in acute mesenteric ischemia. Intestinal resection is inevitable in patients with peritonitis and bowel gangrene. This retrospective study aimed to elucidate the benefit of postoperative parenteral anticoagulation in patients with intestinal resection.

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(1) Background: Hepatocellular carcinoma (HCC) with a large right atrium tumor thrombus (RATT) is a rare and critical presentation. Emergency hepatectomy and thrombectomy under cardiopulmonary bypass (CPB) is life-saving and potentially curative. The aim of this study is to propose an appropriate approach for this condition.

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Article Synopsis
  • En bloc right hemicolectomy plus pancreaticoduodenectomy (cPD) is a surgical procedure for advanced colon cancer affecting the duodenum or pancreatic head, often performed in emergency situations where patients exhibit acute abdominal symptoms.
  • A study retrospectively evaluated 30 patients with locally advanced right colon cancer who underwent cPD, with 11 of those surgeries performed under emergency conditions due to critical issues like bowel obstruction and perforation.
  • Findings showed that while emergency surgery had a higher complication rate (63.6%) compared to non-emergency (42.1%), both groups had similar long-term outcomes without any fatalities related to the cPD procedure.
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Background: Hepatectomy is one potential treatment for intrahepatic cholangiocarcinoma (IHCC). Recurrent rate is high after curative resection and most recurrences occur within residual liver parenchyma. The aim of this study was to elucidate the impact of different treatment modalities on recurrent diseases in patients with IHCC after primary liver resection.

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Hepatitis B virus X protein (HBx) plays critical roles in hepatocellular tumorigenesis by activating different signaling pathways, including the c-Jun NH2-terminal kinase (JNK) pathway. Phosphorylation of paxillin (PXN) promotes cell migration via activation of the JNK signaling pathway, but PXN overexpression is not associated with poor outcome in patients with hepatocellular carcinoma (HCC). HBx gene manipulation and Western blotting indicated that phosphorylation of PXN at Serine 178 (p-PXN) by HBx may promote invasiveness in HCC cells via HBx-mediated JNK activation.

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Background: For hepatocellular carcinoma (HCC), liver resection is a classical curative modality, despite its technical complexity. The incidence of HCC in the oldest old people (aged ≥ 85 years) is rising along with the global increase in life expectancy. Currently, no report has addressed liver resection for HCC in this aged population.

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  • Metabolic risk factors like obesity, fatty liver, high triglycerides, and diabetes are linked to nonviral hepatocellular carcinoma (NBNC-HCC), and a study on 3,843 HCC patients in Taiwan highlighted these associations, particularly in groups without alcohol use or cirrhosis.
  • Out of the patients analyzed, 411 were confirmed as having NBNC-HCC, and these patients displayed more significant metabolic risks compared to those with hepatitis B (HBV) or C (HCV) related HCC.
  • The findings suggest that as viral HCC declines due to vaccinations and treatments, there is a critical need to adapt cancer prevention and monitoring strategies to focus on nonviral risks associated with HCC.
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Background: Hepatitis B virus X (HBx) protein plays critical roles in hepatitis B virus (HBV)-associated hepatocellular tumorigenesis through different molecular mechanisms, including inactivation of p53, a key transcription factor of liver kinase B1 (LKB1). We hypothesized that p53 inactivation by HBx protein could decrease LKB1 expression, thereby promoting tumor progression and poor outcomes in patients with HBV-associated hepatocellular carcinoma.

Methods: Manipulation strategies for HBx protein and/or p53 were used to verify that loss of LKB1 could promote colony formation and invasiveness in HepG2 and Hep3B cells.

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Background: Improvements in antimetabolite drugs have prolonged the survival of patient with hematological malignancies. However, these drugs may have hepatotoxic side effects and may induce acute liver failure, chronic liver fibrosis, cirrhosis, or even hepatocellular carcinoma (HCC). Although liver resection remains a curative option for HCC, its role in HCC with hematological malignancies has never been fully explored.

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  • The study aimed to establish a consensus among expert surgeons on 25 intraoperative findings during laparoscopic cholecystectomy (LC) that may indicate surgical difficulty.
  • A group of surgeons from Japan, Korea, and Taiwan evaluated these findings using a structured Delphi process, achieving high response rates and a final consensus on all items.
  • Among the findings, 'Diffuse scarring in the Calot's triangle area' was identified as having the most significant impact on surgical difficulty, suggesting that increased fibrotic changes and scarring lead to more challenging surgeries.
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Taiwan is a well-known endemic area of hepatitis B. Hepatocellular carcinoma (HCC) has consistently been the first or second highest cause of cancer death over the past 20 years. This review article describes the progress of liver resection for HCC in Taiwan in the past half century.

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Gastric cancer is one of the leading causes of cancer-related mortality worldwide. The majority of gastric cancers are diagnosed at an advanced or metastatic stage, with a 5-year survival rate of ~5-20% and a median overall survival of <1 year. Synchronous occurrence of gastric adenocarcinoma and lymphoma is rare, and thus far there is no consensus regarding their management.

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Background: Generally, surgeons' perceptions of surgical safety are based on experience and institutional policy. Our recent pilot survey demonstrated that the acceptable duration of surgery and criteria for open conversion during laparoscopic cholecystectomy (LC) vary among workplaces.

Methods: A web-based survey was distributed to 554 expert LC surgeons in Japan, Korea, and Taiwan.

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Background: Refractory external pancreatic fistula (REPF) is a rare but troublesome event. Fistulojejunostomy with direct suture of the fistula wall to jejunal wall has been demonstrated as a solution. However, it is sometimes technically difficult and some cases of failure were reported.

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Hepatocellular carcinoma (HCC) is the leading cancer death in Taiwan. Chronic viral hepatitis infections have long been considered as the most important risk factors for HCC in Taiwan. The previously published reports were either carried out by individual investigators with small patient numbers or by large endemic studies with limited viral marker data.

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Article Synopsis
  • Dovitinib and sorafenib are both drugs that help treat a type of liver cancer called hepatocellular carcinoma (HCC) by stopping blood vessels from forming tumors.
  • In a study, both drugs showed similar survival times for patients, with dovitinib at 8.0 months and sorafenib at 8.4 months.
  • Patients taking dovitinib had some side effects like diarrhea and fatigue, but it was found that those with lower levels of certain blood proteins had a better survival rate.
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Background: Circumferential hypopharyngeal defect with simultaneous skin defect can pose complicated reconstructive challenge for reconstructive microsurgeons. Our experience with the versatile inverted-omega flap tubing design is proposed to accommodate such problem.

Methods: From 2012 to 2015, 13 anterolateral thigh (ALT) flaps and one anteromedial thigh (AMT) flap were harvested for reconstruction of circumferential hypopharyngeal defects with skin defects in 14 patients.

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Introduction: Regulator of chromosome condensation 1 (RCC1) is a critical cell cycle regulator. We firstly identified RCC1 gene hypermethylation in gastric tumor tissues using the differential methylation hybridization (DMH) microarray, but the role of RCC1 in the pathogenesis of gastric carcinoma is largely unknown.

Methods: Three gastric cancer cell lines (AGS, MKN45, and TSGH9201) were used to analyze RCC1 gene methylation, mRNA and protein expressions.

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Introduction: Hypermethylation of relevant genes may affect the prognosis of patients with cancer. The purpose of this study was to analyze whether methylation of the promoter regions of cell cycle regulators as well as elevated α-Fetoprotein (AFP) levels are useful prognostic factors for patients with hepatocellular carcinoma (HCC).

Material And Methods: Nested methylation-specific PCR (nested-MSP) was used to analyze methylation status of the promoter regions of p15, p16, p21, p27, and ras-association domain family 1 (RASSF1A) genes in tumor specimens from 50 patients with HCC.

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Mouse embryonic stem cells (ES cells) can proliferate indefinitely. To identify potential signals involved in suppression of self-renewal, we previously screened a kinase/phosphatase expression library in ES cells, and observed that inhibition of Dual Leucine zipper-bearing Kinase (DLK) increased relative cell numbers. DLK protein was detected in both the pluripotent and differentiated states of mouse ES cells while DLK kinase activity increased upon differentiation.

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Background And Objectives: Unroofing hepatectomy, an alternative approach to remove a deep-seated hepatocellular carcinoma (HCC) adjacent to major intrahepatic vessels by peel-off technique after sacrificing the overlying noncancerous liver, may result in tumor exposure without resection margin. The aim of the study was to examine the value of this approach in cirrhotic patients.

Methods: Between 1998 and 2012, 51 cirrhotic patients underwent unroofing hepatectomy for deep-seated newly-diagnosed HCC adjacent to major intrahepatic vessels (group A).

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Background/aims: High operative mortality has been reported after liver resection for hepatocellular carcinoma (HCC) in cirrhotic patients with high preoperative serum alanine aminotransferase (sALT) level. Their long-term prognosis has never been investigated. The aim of this study is to evaluate the benefit of liver resection for HCC in this subgroup of patients.

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Background: The aim of the present study was to clarify both short-term and long-term results of patients with concomitant hepatocellular carcinoma (HCC) and high-risk oesophagogastric varices (OGV).

Methods: This retrospective study identified 927 cirrhotic patients who underwent curative resection of HCC between 1995 and 2012 in single institution. Patients were separated into 3 groups (A, B, and C) according to general rules for recording endoscopic findings of oesophagogastric varices proposed in Japan in 1991.

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