Evaluation of Injectable Chitosan-based Co-cross-linking Hydrogel for Local Delivery of Re-LIPO-DOX to Breast-tumor-bearing Mouse Model.

Background/aim: An injectable chitosan-based co-cross-linking thermosensitive hydrogel combining Re- and doxorubicin-encapsulated liposomes (C/GP/GE/Re-LIPO-DOX) was developed for the prevention of locoregional recurrence after mastectomy.

Materials And Methods: The hydrogel properties, in vitro drug release characteristics, and in vivo scintigraphy imaging attributes were investigated.

Results: The gelation time of the hydrogels can be controlled to be within 5 min.