Publications by authors named "Cheng-Chen Tai"
Article Synopsis
- - Sulfamethoxazole (SMX) and cotrimoxazole (CTX) are widely used antibacterial medications, but have been linked to severe cutaneous adverse reactions (SCARs) in some patients, and the role of specific HLA genotypes in this risk remains unclear.
- - This study sought to determine the relationship between various HLA genotypes and the incidence of SCARs caused by SMX and CTX by analyzing data from case-control studies.
- - The analysis included six studies with a total of 322 patients experiencing SCARs; significant associations were found between specific HLA alleles (HLA-A*11:01, HLA-B*13:01) and increased odds of developing SCAR
Article Synopsis
- Recent clinical practice guidelines (CPGs) for managing urticaria were reviewed to assess their quality and identify gaps in treatment recommendations for chronic spontaneous urticaria.
- A total of 21 CPGs were analyzed, primarily from European and Asian countries, revealing that 81% scored poorly in critical appraisal domains such as applicability and stakeholder involvement.
- Most guidelines displayed potential biases, with 86% raising serious concerns about the involvement of experts and external review, and 95% failing to meet established trustworthiness standards in areas like updating procedures.
Background: Current practice guidelines for optimal infusion rates during early intravenous hydration in patients with acute pancreatitis (AP) remain inconsistent. This systematic review and meta-analysis aimed to compare treatment outcomes between aggressive and non-aggressive intravenous hydration in severe and non-severe AP.
Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Background And Objectives: To compare the efficacy and safety of biologic treatments for moderate-to-severe pediatric psoriasis approved by the US Food and Drug Administration and European Medicines Agency.
Patients And Methods: MEDLINE, Embase, and Cochrane Central Register of Controlled Trials for relevant randomized controlled trials (RCTs) were searched for the identification of eligible RCTs until May 7, 2021. Fixed-effect frequentist network meta-analysis (NMA) was performed with the surface under the cumulative ranking curve (SUCRA) calculated for ranking.
Article Synopsis
- Treatment guidelines for hidradenitis suppurativa (HS) differ across countries, with various biologics and small molecule inhibitors evaluated for moderate-to-severe cases.
- A systematic review and meta-analysis analyzed 16 randomized controlled trials involving 2076 participants to assess the effectiveness and safety of these treatments.
- The analysis found that only adalimumab and bimekizumab significantly improved HS symptoms, with adalimumab also showing a notable positive impact on patients' quality of life, and no increased serious adverse events compared to placebo.
Background: Clinical practice guidelines (CPGs) developed with rigorous methods can help optimize clinical care for patients with psoriasis.
Objectives: To conduct an updated systematic review and comprehensive critical appraisal of global psoriasis CPGs.
Methods: A search of MEDLINE and Embase for psoriasis CPGs published between 1 January 2015 and 31 March 2021 was performed.