Publications by authors named "Cheng-Chen Shao"
Objectives: To identify whether the relationship between Zhang A, Zhang B, Zhang C and Zhang X is the half-sibling relationship whose mother is sister (hereinafter referred to as the special half-sibling relationship) or the common first cousin relationship and discuss the application of ITO method in discriminating the special kinship.
Methods: DNA was extracted from blood stain of four identified individuals, PowerPlex 21 System and AGCU 21+1 STR kit were used to detect autosomal STR genetic markers. Investigator Argus X-12 QS kit was used to detect the X chromosome STR genetic markers, the special half-sibling index (SHSI) and first cousin index (FCI) and their likelihood ratio (LR) were calculated by ITO method.
RNA has received more attention in the field of forensic medicine and the development of the new biological markers based on RNA shows great significance in the analysis of complex cases. circular RNA (circRNA) is a kind of non-coding RNA which is widely reported recently. Although the regulatory mechanisms of generation and expression are not fully clear, the existing research indicates that circRNA has important biological functions.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between the ratio of STR loci to the Amelogenin (AMEL) locus in degraded DNA and aims to determine how this ratio can be used to estimate the extent of DNA degradation.
- Researchers extracted DNA from iliopsoas muscle and assessed changes in the STR/AMEL ratios after artificial and natural degradation processes.
- Results indicate a strong negative correlation between STR/AMEL values and degradation time, suggesting that these ratios can effectively quantify DNA degradation using mathematical models.