Publications by authors named "Cheng-Che E Lan"
Article Synopsis
- - The study investigates how high-glucose (HG) environments affect the response of human epidermal keratinocytes (HEKs) to UVB radiation, which is known to cause skin cancer.
- - Researchers found that while both normal-glucose (NG) and HG conditions induced consistent responses to UVB, HG specifically triggered distinct processes related to cellular function and gene expression, including the activation of a key tumor suppressor gene, TFPI2.
- - Under high-glucose conditions, HEKs exhibited increased oxidative stress, reduced cell viability, and heightened apoptosis after UVB exposure, suggesting that high glucose may alter keratinocytes' behavior and lower their photocarcinogenic potential.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, rare skin reactions primarily triggered by drugs, leading to significant health risks and complications.
- The review suggests new diagnostic criteria to better identify these conditions and highlights recent research on how specific immune responses and genetic factors contribute to their development.
- It also discusses current and emerging treatment options, including debates on immunosuppressive therapies and new drug developments targeting specific mechanisms involved in SJS/TEN, advocating for a more collaborative approach in medical research to improve patient care.
Several studies have reported an association between dipeptidyl peptidase 4 inhibitor (DPP4i), a commonly prescribed second-line oral antihyperglycemic drug, and bullous pemphigoid (BP). However, the benefits of DPP4i withdrawal in patients with BP remain controversial. This study primarily aimed to evaluate the clinical severity of DPP4i-associated BP by comparing it to those without Type 2 diabetes mellitus (DM).
View Article and Find Full Text PDFResponse predictor for pigment reduction after one session of photo-based therapy using convolutional neural network: A proof of concept study.
Photodermatol Photoimmunol Photomed
September 2023
Background: Identifying treatment responders after a single session of photo-based procedure for hyperpigmentary disorders may be difficult.
Objectives: We aim to train a convolutional neural network (CNN) to test the hypothesis that there exist discernible features in pretreatment photographs for identifying favorable responses after photo-based treatments for facial hyperpigmentation and develop a clinically applicable algorithm to predict treatment outcome.
Methods: Two hundred and sixty-four sets of pretreatment photographs of subjects receiving photo-based treatment for esthetic enhancement were obtained using the VISIA® skin analysis system.
Background: Coronavirus disease 2019 (COVID-19) pandemic has caused changes in the medical practice. However, it is unclear whether the patients receiving phototherapy for their dermatoses have been affected.
Objectives: This study aimed to identify the impact of the COVID-19 pandemic on phototherapy, focusing on the patient profile, adherence, and attitude before and after the surge.
The Epidermal Keratinocyte as a Therapeutic Target for Management of Diabetic Wounds.
Int J Mol Sci
February 2023
Article Synopsis
- Diabetes mellitus is a major cause of chronic wounds and non-traumatic amputations, with its prevalence on the rise globally.
- The dysfunction of keratinocytes, the skin cells vital for wound healing, is exacerbated by high glucose levels, leading to issues like prolonged inflammation and poor healing.
- Understanding the molecular mechanisms behind keratinocyte dysfunction in high glucose conditions can help develop effective treatments for diabetic wound healing.
Article Synopsis
- - The study investigates how human epidermal keratinocytes (HEKs) behave in wound healing, particularly in the context of diabetes, where wound healing is often impaired due to high glucose levels.
- - Researchers cultured HEKs in normal and high-glucose environments and found that high glucose significantly changes gene expression, particularly increasing certain key genes linked to cellular responses during wound healing.
- - Findings reveal that high-glucose conditions activate specific signaling pathways in keratinocytes, suggesting these changes contribute to the complications seen in diabetic wounds, and the study proposes this model could help develop personalized treatments.
Impact of Vitiligo on Life Quality of Patients: Assessment of Currently Available Tools.
Int J Environ Res Public Health
November 2022
Background: How different tools for evaluating health-related quality of life (QoL) reflect the burden of vitiligo has rarely been compared. In this study, we aim to evaluate the impact of vitiligo on QoL using currently available tools.
Methods: A single-center, cross-sectional study of vitiligo patients was performed.
Objectives: Laser therapy has become one of the mainstay treatments for improving signs of aging including wrinkles, large pores, and skin pigmentation. However, in patients with pigmented skin, an increase in complications including post-inflammatory hyperpigmentation (PIH) has been noted. The purpose of this study is to investigate not only the safety profile of 755-nm picosecond laser with diffractive lens array (DLA) at approximately 2250 pulses on the face in people with darker skin, but also to evaluate its efficacy in treating wrinkles and pore sizes after one treatment session among different age groups.
View Article and Find Full Text PDFArticle Synopsis
- Combining low-dose tofacitinib with 308-nm excimer light therapy shows potential as a new treatment for patients with nonsegmental vitiligo.
- This combination therapy could be beneficial for those who haven't responded to traditional treatments.
- The findings suggest a promising option for better managing vitiligo symptoms in resistant cases.
Aims: Sunscreen use, which prolonged the time required to develop sunburn by reducing the irradiance (mW/cm) of the UVB radiation, is thought to protect the skin from developing cancers. Recently, in addition to fluence (mJ/cm), irradiance of the UVB radiation was demonstrated to play an important role leading to photocarcinogenesis of the skin. After equivalent fluence of UVB exposure, enhanced aberrant keratinocyte proliferation contributes significantly to the photocarcinogenic capacity of low irradiance (LI) UVB as compared to its high irradiance (HI) UVB counterpart.
View Article and Find Full Text PDFBackground: How diseases associated with skin discoloration affect the quality of life (QoL) has rarely been examined. In this study, we directly compared the QoL and willingness to pay (WTP) among patients with skin disorders associated with facial discoloration.
Methods: A single-center, cross-sectional study consisting of patients seeking treatment for facial discoloration was performed.