Publications by authors named "Cheng-Bin Qu"
[Application of "kindergarten effect" in radiotherapy for children with tumor aged 3-5 years].
Zhongguo Dang Dai Er Ke Za Zhi
June 2022
Objectives: To study the clinical application effect of "kindergarten effect" in radiotherapy for children with tumor based on the psychology of preschool children aged 3-5 years.
Methods: A total of 30 children, aged 3-5 years, who were admitted to the Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, from January 2020 to August 2021 were enrolled in this prospective study. The children were randomly divided into a control group and a test group, with 15 children in each group.
MiR-143 enhances the antitumor activity of shikonin by targeting BAG3 expression in human glioblastoma stem cells.
Biochem Biophys Res Commun
March 2016
Therapeutic applications of microRNAs (miRNAs) in chemotherapy were confirmed to be valuable, but there is rare to identify their specific roles and functions in shikonin treatment toward tumors. Here, for the first time, we reported that miR-143 played a critical role in the antitumor activity of shikonin in glioblastoma stem cells (GSCs). The results showed that the expression of miR-143 was downregulated in shikonin treated GSCs within 24 h.
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- A study reveals that shikonin, known for inducing cell death in tumors, also activates protective mechanisms in glioblastoma stem cells (GSCs), reducing their sensitivity to shikonin's effects.
- Researchers found that shikonin treatment led to reduced active caspase-9 and increased mitochondrial membrane potential in GSCs, indicating a survival response.
- By inhibiting Endoplasmic Reticulum Stress (ERS) with a compound called 4-PBA, the cytotoxic effects of shikonin were enhanced in GSCs, suggesting targeting ERS could improve shikonin's effectiveness in cancer therapy.