Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections.

Vancomycin is primarily used to treat severe infections caused by Gram-positive bacteria and is often considered as the last-resort therapy in the life-threatening situation. However, it is inherently ineffective against Gram-negative bacteria. Herein, we report the design, synthesis, and biological evaluation of novel vancomycin analogues incorporated with lipophilic cationic groups.

Targeting GDF15 to enhance immunotherapy efficacy in glioblastoma through tumor microenvironment-responsive CRISPR-Cas9 nanoparticles.

Despite the outstanding clinical success of immunotherapy, its therapeutic efficacy in glioblastoma (GBM) is still limited. To identify critical regulators of GBM immunity, we constructed a mouse single-guide RNA (sgRNA) library corresponding to all disease-related immune genes, and performed an in vivo CRISPR knockout (KO) screen in syngeneic GBM mouse models. We demonstrated that the deletion of GDF15 in GBM cells ameliorated the immunosuppressive tumor microenvironment (TME) and enhanced the antitumor efficacy of immune checkpoint blockade (ICB) response.

Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade.

Glioblastoma (GBM) is a primary brain tumor known for its high levels of aggressiveness and resistance to current treatments such as radiotherapy and chemotherapy. As a result, there is a pressing need for innovative therapeutic approaches to combat GBM. Thus, we have developed an engineered multifunctional extracellular vesicle (EV) delivery system that offers an "all-in-one" strategy for GBM therapy.

In Vitro and In Vivo Anticancer Activities of Water-Soluble Ru(II)(η6--cymene) Complexes via Activating Apoptosis Central Regulators and Possibilities of New Antitumor Strategies in Triple Negative Breast Cancers.

In this study, we synthesized 12 monofunctional tridentate ONS-donor salicylaldimine ligand ()-based Ru(II) complexes with general formula [(Ru()(-cymene)]·Cl (-), characterized by H NMR, C NMR, UV, FT-IR spectroscopy, HR-ESI mass spectrometry, and single-crystal X-ray analysis showing ligand's orientation around the Ru(II) center. All 12 of these 12 complexes were tested for their anticancer activities in multiple cancer cells. The superior antitumor efficacy of , , and was demonstrated by reduced mitochondrial membrane potential, impaired proliferative capacity, and disrupted redox homeostasis, along with enhanced apoptosis through caspase-3 activation and downregulation of Bcl-2 expression.

A novel susceptibility locus to () identified by genetic mapping of automated microscopy computer vision data in grapevines.

Powdery mildew, caused by the fungus , is one of the primary causes of grape yield loss across the globe. While numerous resistance loci have been identified in various grapevine species, the genetic determinants of susceptibility to remain largely unexplored. Understanding the genetics of susceptibility for pathogenesis is equally important for developing durable resistance grapevines against this pathogen.

A multi-responsive 3D deformable soft actuator with tunable structural color enabled by a graphene/cholesteric liquid crystal elastomer composite.

Intelligent soft robots that integrate both structural color and controllable actuation ability have attracted substantial attention for constructing biomimetic systems, biomedical devices, and soft robotics. However, simultaneously endowing single-layer cholesteric liquid crystal elastomer (CLCE) soft actuators with reversible 3D deformability and vivid structural color changes is still challenging. Herein, a multi-responsive (force, heat and light) single-layer 3D deformable soft actuator with vivid structural color-changing ability is realized through the reduced graphene oxide (RGO) deposition-induced Janus structure of the CLCE using a precisely-controlled evaporation method.

A Spectrum-Tailored Polymer Dispersed Liquid Crystal Film for Energy-Saving Smart Windows.

The polymer dispersed liquid crystal (PDLC) holds potential application in smart windows, owing to its feasibility in regulating the transmittance of specific wavelength bands to improve energy utilization. Herein, a composite PDLC smart window is designed, which showcases high emissivity of 93.79% in the mid-infrared region and features the regulation of ultraviolet (UV), visible, and near-infrared (NIR) light.

A Multi-Functional Molecule for Highly Durable, Bending-Resistant, Low-Voltage Driving PSLC Films toward Smart Windows With Radiative Cooling.

Polymer-stabilized liquid crystals (PSLCs) are widely used in smart windows, light modulators, and dimmed glass. However, their low mechanical strength, unsatisfactory electro-optical properties, and poor durability limit their large-scale application. In this study, a PSLC film with outstanding performance is prepared by incorporating a multifunctional molecule into a fine-sculptured liquid crystal/polymer composite.

Heteroatom-Terminated Acrylate-Based Polymer-Dispersed Liquid Crystal Composite Films with High Contrast Ratio and Low Driving Voltage.

A series of polymer-dispersed liquid crystal (PDLC) films were prepared by using acrylate monomers containing heteroatom-terminated groups. The microscopic morphology and electro-optical properties reveal that these monomers effectively reduce the switching voltage and improve the contrast ratio at the same time. The saturation voltage of the best sample was reduced by 47%, and the contrast ratio was improved by 74%.

Comprehensive Characterization of the Integrin Family Across 32 Cancer Types.

Integrin genes are widely involved in tumorigenesis. Yet, a comprehensive characterization of integrin family members and their interactome at the pan-cancer level is lacking. Here, we systematically analyzed integrin family in approximately 10,000 tumors across 32 cancer types.

Photoelectric HS Sensing Based on Electrospun Hollow CuO-SnO Nanotubes at Room Temperature.

Pure tin oxide (SnO) as a typical conductometric hydrogen sulfide (HS) gas-sensing material always suffers from limited sensitivity, elevated operation temperature, and poor selectivity. To overcome these hindrances, in this work, hollow CuO-SnO nanotubes were successfully electrospun for room-temperature (25 °C) trace HS detection under blue light activation. Among all SnO-based candidates, a pure SnO sensor showed no signal, even toward 10 ppm, while the 1% CuO-SnO sensor achieved a limit of detection (LoD) value of 2.

Study on the Polymer Morphology and Electro-Optical Performance of Acrylate/Epoxy Resin-Based Polymer-Stabilized Liquid Crystals Based on Stepwise Photopolymerization.

Stepwise photopolymerization is a miraculous strategy modulating the polymer skeleton and electro-optical properties of light modulators based on liquid crystal/polymer composites. However, owing to the indistinct polymerization mechanism and curing condition discrepancy, the required polymer structures and electro-optical properties are hard to be controlled precisely. Herein, a novel polymer-stabilized liquid crystal film based on acrylate/epoxy resin is proposed, fabricated and the relationships between preparation process, polymer content, polymer morphology and electro-optical properties are studied.

Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β/Smad and p38MAPK signaling pathways.

Pulmonary fibrosis (PF) is an interstitial lung disease characterized by inflammation and fibrotic changes, with an unknown cause. In the early stages of PF, severe inflammation leads to the destruction of lung tissue, followed by upregulation of fibrotic factors like Transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF), which disrupt normal tissue repair. Geniposide, a natural iridoid glycoside primarily derived from the fruits of Gardenia jasminoides Ellis, possesses various pharmacological activities, including liver protection, choleretic effects, and anti-inflammatory properties.

Reverse-Mode Polymer-Stabilized Liquid Crystal Films with Enhanced Peel Strength and Electro-Optical Performance Based on Photoreactive Self-Assembly Alignment Layers and Patterned Polymer Walls.

Polymer-stabilized liquid crystal (PSLC) is a promising material toward the practical application of serving as energy-saving reverse-mode smart windows owing to its superior electro-optical (E-O) properties, simple and efficient processability, and compatibility to most practical circumstances. However, its feeble peel strength originated from low polymer content and poor adhesion between polymer networks and substrates inhibited its large-scale flexible film production. It is still a challenging task to derive good mechanical properties and superior E-O performance for PSLCs at the same time.

Research on path planning for clear aligner flexible manufacturing.

In recent years, clear aligner can enhance individual appearance with dental defects, so it used more and more widely. However, in manufacturing process, there are still some problems, such as low degree of automation and high equipment cost. The problem of coordinate system mismatch between gingival curve point cloud and dental CAD model is faced to.

Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study.

Mutations in IDH1 are commonly observed across various cancers, causing the conversion of α-KG to 2-HG. Elevated levels of 2-HG disrupt histone and DNA demethylation processes, promoting tumor development. Consequently, there is substantial interest in developing small molecule inhibitors targeting the mutant enzymes.

A Smart Window with Passive Radiative Cooling and Switchable Near-Infrared Light Transmittance via Molecular Engineering.

Smart windows with synergetic light modulation have heightened demands for applications in smart cars and novel buildings. However, improving the on-demand energy-saving efficiency is quite challenging due to the difficulty of modulating sunlight with a broad bandwidth in an energy-saving way. Herein, a smart window with switchable near-infrared light transmittance and passive radiative cooling is prepared via a monomer design strategy and photoinduced polymerization.

Discovery of novel Thymol-TPP antibiotics that eradicate MRSA persisters.

The high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strains and the formation of non-growing, dormant "persisters" subsets help bacteria evade antibiotic treatment and enhance bacterial resistance, which poses a serious threat to human life and health. It is urgent to discover novel antibacterial therapies effective against MRSA persisters. Thymol is a common nutraceutical with weak antibacterial and antitumor activities.

Oxygen Vacancy-Rich Bimetallic Au@Pt Core-Shell Nanosphere-Functionalized Electrospun ZnFeO Nanofibers for Chemiresistive Breath Acetone Detection.

Sensitive and selective acetone detection is of great significance in the fields of environmental protection, industrial production, and individual health monitoring from exhaled breath. To achieve this goal, bimetallic Au@Pt core-shell nanospheres (BNSs) functionalized-electrospun ZnFeO nanofibers (ZFO NFs) are prepared in this work. Compared to pure NFs-650 analogue, the ZFO NFs/BNSs-2 sensor exhibits a stronger mean response (3.

An integrated ceRNA network identifies miR-375 as an upregulated miRNA playing a tumor suppressive role in aggressive prostate cancer.

Prostate cancer (PCa) remains a significant cause of morbidity and mortality among men worldwide. A number of genes have been implicated in prostate tumorigenesis, but the mechanisms underlying their dysregulation are still incompletely understood. Evidence has established the competing endogenous RNA (ceRNA) theory as a novel regulatory mechanism for post-transcriptional alterations.