Dynamic Pathophysiological Insight into the Brain by NIR-II Imaging.

Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing the need for accurate and in vivo diagnostic tools that can afford valuable pathophysiological insight into the functioning of neurovascular unit in space and time. Currently, understanding of collateral perfusion and BBB evolution under both physiological and pathological conditions remains sparse, largely owing to limitations in methods for recording diminutive route of cerebral blood flow. Here, it is reported that highly crystalline semiconducting organic nanoprobes (named 4T-BSA) composed of small-molecule dye and bovine serum albumin showed vast potential for live-brain vascular imaging in the second near-infrared window (NIR-II, 1000-1700 nm).

Neural Network with Attention Mechanism for Abnormality Detection and Localization in Diffusive Molecular Communication.

Diffusive molecular communication (DMC) is an emerging paradigm in nanotechnology, which provides biocompatibility and nanoscale communication for many promising applications, such as targeted drug delivery, environmental monitoring, etc. However, detecting and localizing abnormalities in most of these applications is challenging, such as identifying tumor cells within the body or detecting pollution in air or water. In this paper, we introduce a method for detecting and localizing abnormalities in three dimensional DMC system with multiple sensors, receivers and one fusion center by adopting Transformer-based model with attention mechanism.

Long-term outcomes of mesenchymal stem cell therapy in severe COVID-19 patients: 3-year follow-up of a randomized, double-blind, placebo-controlled trial.

Background: The long-term effects and outcomes of human mesenchymal stem cell (MSC) therapy in patients with severe coronavirus disease 2019 (COVID-19) remain poorly understood. This study aimed to evaluate the extended safety and efficacy of MSC treatment in severe patients with COVID-19 who participated in our earlier randomized, double-blind, placebo-controlled clinical trial, with follow-up conducted over 3 years.

Methods: One hundred patients with severe COVID-19 were randomized to receive either an MSC infusion (n = 65, 4 × 10 cells/dose, on days 0, 3, and 6) or a placebo, with both groups receiving the standard of care.

Near-infrared fluorescence imaging with an MET-targeting probe for biopsy site selection in patients with oral potentially malignant disorders.

Accurate detection of malignant transformation in oral potentially malignant disorders (OPMDs) is crucial for guiding effective treatment and improving patient management. This study evaluates the potential of MET-binding peptide-indocyanine green (cMBP-ICG), a mesenchymal-epithelial transition factor (MET)-targeted near-infrared fluorescence imaging (NIRFI) probe, for biopsy site selection in OPMDs. Preclinical results demonstrate the superior accuracy of NIRFI-assisted biopsy over conventional oral examination (COE)-based biopsy in detecting high-grade dysplasia (HGD) or squamous cell carcinoma (SCC) and reducing missed detection rates.

Nickel-doped δ-MnO abundant in oxygen vacancies as a cathode material for aqueous Zn-ion batteries with superior performance.

Manganese oxide is widely considered as a prominent cathode material for Zn-ion batteries (ZIBs) because of its merits including low cost, high voltage, non-toxicity and excellent stability. However, its sluggish reaction kinetics and structural instability limit its practical application in ZIBs. In this paper, a one-step method for preparing nickel-doped δ-MnO (Ni-δ-MnO) at room temperature is introduced.

A biomimetic dual-targeting nanomedicine for pancreatic cancer therapy.

The physiological characteristics of pancreatic cancer (PC) involve the interplay between tumor cells, cancer-associated fibroblasts (CAF) and the extracellular matrix (ECM). This intricate microenvironment contributes to the cancer's resistance to conventional chemoradiotherapy and its poor prognosis. Carbon monoxide (CO), a promising molecule in gas therapy, can effectively penetrate solid tumors and induce tumor cell apoptosis at high concentrations.

Comparison of the content of taste and nutrition-related non-volatile compounds in cultivated and wild blueberry varieties in Northeast China.

This study compared the taste and nutrition related metabolites of wild blueberry (WB) and cultivated blueberry (CB) varieties in Northeast China based on widely targeted metabolomics. A total of 858 metabolites were identified, of which 254 showed significant differences. 16 carbohydrates were significantly higher in CBs than in WB, while 11 organic acids were the opposite.

The spectrum and prognosis of Sjögren's syndrome with membranous nephropathy.

Background: This study aims to investigate the spectrum and prognosis of membranous nephropathy (MN) in patients with Sjögren's syndrome (SS).

Methods: SS patients with biopsy-proven kidney involvement who were diagnosed at our center between April 2007 and February 2024 were retrospectively reviewed and analyzed.

Results: A total of 290 SS patients with kidney involvement were enrolled.

Continuity and volume of bone cement and anti osteoporosis treatment were guarantee of good clinical outcomes for percutaneous vertebroplasty: a multicenter study.

Background: As the most prevalent fragility fracture caused by osteoporosis, increasing attention was paid to vertebral compression fractures (VCF) day by day. Percutaneous vertebroplasty (PVP) had unique advantages in treatment of VCF and was used widely. However, there were still part patients suffering from residual or unrelieved pain after the surgery.

Ferroelectric Optoelectronic Memory Based on p-GaN/ZnGaO/BaTiO/n-ITO Heterojunction with Integrated Sensing and Logic Operations.

Ferroelectric optoelectronic memories, capable of integrating sensing, computing, and storage functionalities, hold significant potential in the fields of artificial intelligence and the Internet of Things. In this study, a nonvolatile p-GaN/ZnGaO/BaTiO/n-ITO ferroelectric optoelectronic memory is demonstrated. By combining with wide-bandgap semiconductors ZnGaO and GaN, known for their excellent optoelectronic properties, the device exhibits superior self-powered ultraviolet photodetection performance.

Near-Infrared-II Fluorescent Probes for Analytical Applications: From Detection to Imaging Monitoring.

ConspectusBiomarkers play a vital role in the regulation of life processes, especially in predicting the occurrence and development of diseases. For the early diagnosis and precise treatment of diseases, it has become necessary and significant to detect biomarkers with sensitivity, accuracy, simplicity, convenience, and even visualization. Fluorescent-probe-based techniques have been recognized as one of the most powerful tools for the sensitive detection and real time imaging of biomarkers in biological samples.

Severe cutaneous drug toxicity following disitamab vedotin treatment for metastatic gastric cancer: a case report.

Background: This study reports a case of severe cutaneous toxicity in a patient with metastatic gastric cancer induced by disitamab vedotin, emphasizing the need for careful monitoring and management in such treatments.

Case Presentation: A 71-year-old female was admitted to hospital complaining of serious rashes following the first cycle of disitamab vedotin regimen for metastatic gastric cancer. The doctor diagnosedtoxic epidermal necrolysis (TEN) induced by the drug.

Applications of modified lignocellulose and its composites prepared by different pretreatments in biomedicine: A review.

Lignocellulosic biomass represents one of the most abundant renewable biological resources on earth. Despite its current underutilization as a source of high-value chemicals, it has promising applications in biomedical and other fields. Presently, lignocellulose is predominantly transformed into high-value-added products, e.

Fibroblast activation protein peptide-targeted NIR-I/II fluorescence imaging for stable and functional detection of hepatocellular carcinoma.

Purpose: Cancer-associated fibroblasts (CAFs) are the primary stromal component of the tumor microenvironment in hepatocellular carcinoma (HCC), affecting tumor progression and post-resection recurrence. Fibroblast activation protein (FAP) is a key biomarker of CAFs. However, there is limited evidence on using FAP as a target in near-infrared (NIR) fluorescence imaging for HCC.

L-selectin Promotes Migration, Invasion and Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via NF-kB Signaling Pathway.

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by chronic inflammation of the synovium and progressive joint damage. Fibroblast-like synoviocytes (FLSs) exhibit excessive proliferative and aggressive phenotypes and play a major role in the pathophysiology of RA. Previous studies have confirmed the pathologic role of L-selectin in cell adhesion and migration.

Synergistic Modulation of Solid- and Cathode-Electrolyte Interphase via a Lithium Salt Additive toward Stable Sodium Metal Batteries.

Constructing feasible sodium metal batteries (SMBs) faces complex challenges in stabilizing cathodes and sodium metal anodes. It is imperative, but often underemphasized, to simultaneously regulate the solid-electrolyte interphase (SEI) to counter dendrite growth and the cathode-electrolyte interphase (CEI) to mitigate cathode deterioration. Herein, we introduce lithium 2-trifluoromethyl-4,5-dicyanoimidazolide (LiTDI) as an efficacious additive in a carbonate-based electrolyte to extend cycle lifespan of full SMBs: the capacity retention reaches 77.

Risk Factors, Clinical Characteristics, and Antibiotic Susceptibility Patterns of Keratitis: An 18-Year Retrospective Study from a Tertiary Hospital in China.

Our aim was to investigate risk factors, clinical characteristics, and antibiotic susceptibility patterns of cornea-isolated species collected at a tertiary hospital in China over 18 years. This retrospective study reviewed data from 350 patients diagnosed with keratitis at Beijing Tongren Hospital between January 2006 and December 2023, including demographics, risk factors, clinical signs, in vivo confocal microscopy (IVCM) imaging, and antibiotic susceptibility testing. The predominant type was (n = 108, 29.

Molecular imaging-guided diagnosis and treatment integration for brain diseases.

In practical clinical scenarios, improved diagnostic methods have been developed for the precise visualization of molecular targets using molecular imaging in brain diseases. Recently, the introduction of innovative molecular imaging modalities across both macroscopic and mesoscopic dimensions, with remarkable specificity and spatial resolution, has expanded the scope of applications beyond diagnostic testing, with the potential to guide therapeutic interventions, offering real-time feedback in the context of brain therapy. The molecular imaging-guided integration of diagnosis and treatment holds the potential to revolutionize disease management by enabling the real-time monitoring of treatment responses and therapy adjustments.

Utilizing the Elimination Reaction of Linear Fluorinated Carbonate to Stabilize LiCoO Cathode up to 4.6 V.

Stabilizing LiCoO (LCO) cathode at high voltages is still challenging in lithium-ion batteries (LIBs). Although fluorinated solvents are utilized in high-voltage systems for their superior oxidation resistance, linear fluorinated carbonates still undergo elimination reactions at high voltages, producing corrosive substances that compromise electrode materials. This study addresses the elimination reaction of methyl trifluoroethyl carbonate (FEMC) by incorporating tris(trimethylsilyl)-based additives, thereby constructing a homogeneous and robust polymer-rich cathode-electrolyte interphase (CEI).

Purified components of red-edge tea polysaccharide alleviate food allergy in mice by regulating intestinal homeostasis.

Previous studies found red-edge tea polysaccharides (RETPS)-3 and 4 have anti-allergic effects. To investigate the anti-food allergy activity of the RETPS-3/4, the ovalbumin-induced Balb/c mouse food allergy model was established. Food allergy symptoms, serum inflammatory factors, spleen and intestinal pathology were analyzed.

Preclinical Evaluation and Pilot Clinical Study of CD137 PET Radiotracer for Noninvasive Monitoring Early Responses of Immunotherapy.

Given the variability in the effectiveness of immune checkpoint blocking therapy among patients and tumor types, development of noninvasive methods for longitudinal assessment of immune cell function and early tumor response is crucial for precision immunotherapy. CD137 (4-1BB), a marker of activated T cells, plays a significant role in immunotherapy. However, its potential as an imaging biomarker for activated T cells in the tumor microenvironment has not been explored.

Management of traumatic duodenal rupture in children-case series.

Background: Traumatic duodenal rupture is rare which accounts for only 2-10% of all Blunt abdominal trauma. The purpose of this study was to investigate the experience of diagnosis and treatment of traumatic duodenal rupture in children.

Methods: This was a retrospective case series study.