Publications by authors named "Cheng Y"

Background: Membranous nephropathy (MN) has not yet been fully elucidated regarding its relationship with Type I and II Diabetes. This study aims to evaluate the causal effect of multiple types of diabetes and MN by summarizing the evidence from the Mendelian randomization (MR) study.

Methods: The statistical data for MN was obtained from a GWAS study encompassing 7979 individuals.

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Precious metals are valuable materials for the chemical industry, but they are scarce and pose a risk of supply disruption. Recycling precious metals from waste is a promising strategy, here we tactfully utilize light irradiation as an environmental-friendly and energy-saving adjunctive strategy to promote the reduction of precious metal ions, thereby improving the adsorption capacity and kinetics. A newly light-sensitive covalent organic framework (PP-COF) was synthesized to illustrate the effectiveness and feasibility of this light auxiliary strategy.

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  • Macular hole (MH) formation is uncommon after surgery for rhegmatogenous retinal detachment (RRD) and usually requires another surgery for repair, but spontaneous closure of these holes is even rarer.
  • This study retrospectively analyzed three RRD patients who developed secondary MH after vitrectomy, documenting their cases and the outcomes of spontaneous closure over time.
  • Findings suggested that the initial formation of MH may be linked to vitreomacular traction (VMT), and the release of this traction may facilitate the spontaneous healing of the macular hole.
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The speech-driven facial animation technology is generally categorized into two main types: 3D and 2D talking face. Both of these have garnered considerable research attention in recent years. However, to our knowledge, the research into 3D talking face has not progressed as deeply as that of 2D talking face, particularly in terms of lip-sync and perceptual mouth movements.

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  • Triasulfuron is a sulfonylurea herbicide that inhibits the enzyme AHAS, important for amino acid synthesis.
  • The study analyzed the crystal structures of AHAS with triasulfuron and two new herbicides, FMO and CMO, revealing different binding interactions.
  • All compounds are strong inhibitors of AHAS, with triasulfuron used at 10-15 g/ha in wheat and FMO/CMO effective at 7.5-30 g/ha against barnyard grass, highlighting the role of accumulative inhibition in herbicide activity.
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  • The treatment of infected bone defects (IBDs) requires both eliminating infection and promoting bone regeneration, but iron competition between pathogens and host cells creates a disadvantageous microenvironment.
  • A new method involves using iron-active multifunctional scaffolds made from iron gallate-modified hydroxyapatite and poly(lactic-co-glycolic acid) to create a composite that enhances healing.
  • Tests show that these scaffolds not only fight bacteria through photothermal effects but also restore iron balance, leading to reduced inflammation and improved bone repair, indicating their potential for future clinical use.
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  • Pemphigus vulgaris (PV) is a rare autoimmune skin disease, with its exact causes still not fully understood, prompting research into its underlying cellular mechanisms using advanced proteomic techniques like LC-MS/MS.
  • The study involved analyzing proteins extracted from skin biopsies of PV patients compared to healthy controls, identifying 880, 605, and 586 differentially expressed proteins across different skin conditions, with a particular focus on the activation of the oxidative phosphorylation (OXPHOS) pathway in keratinocytes.
  • Treatments with the OXPHOS inhibitor metformin and the JAK1 inhibitor tofacitinib showed promising effects by reducing cell separation caused by PV serum, underscoring the potential role of both the OXPH
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Green hydrogen energy, as one of the most promising energy carriers, plays a crucial role in addressing energy and environmental issues. Oxygen evolution reaction catalysts, as the key to water electrolysis hydrogen production technology, have been subject to durability constraints, preventing large-scale commercial development. Under the high current density and harsh acid-base electrolyte conditions of the water electrolysis reaction, the active metals in the catalysts are easily converted into high-valent soluble species to dissolve, leading to poor structural durability of the catalysts.

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Background: Wheat is one of major sources of human cadmium (Cd) intake. Reducing the grain Cd concentrations in wheat is urgently required to ensure food security and human health. In this study, we performed a field experiment at Wenjiang experimental field of Sichuan Agricultural University (Chengdu, China) to reveal the effects of FeCl and Fe(SO) on reducing grain Cd concentrations in dwarf Polish wheat (Triticum polonicum L.

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Submandibular gland (SMG) excision via axillary is a brand new technique and we presented its own unique advantages compared with retroauricular and transoral approaches. The single-port (SP) robotic system offers improved visualization of the view and enhanced flexibility of instruments, ensuring optimal stability and dissection in this surgery. We reported the first case of transaxillary SMG excision using single-port robotic system made in China.

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  • Age-related macular degeneration (AMD) features large choroidal hypertransmission defects (hyperTDs), which are bright lesions detected via optical coherence tomography (OCT) and indicate loss of retinal pigment epithelium (RPE).
  • Large hyperTDs tend to persist over time, making them critical for understanding the progression from intermediate to late-stage atrophic AMD and useful as endpoints in clinical trials for potential therapies.
  • In a study monitoring 202 AMD eyes for nearly 47 months, a vast majority (99.6%) of the large hyperTDs remained persistent, while only a few showed non-persistence, mainly due to changes in the RPE and retinal area where the hyperTDs were present.
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  • Biallelic loss of CDK12 is linked to a specific subtype of metastatic castration-resistant prostate cancer (mCRPC), raising questions about its role in cancer development versus exposing drug targets.
  • Research shows that loss of CDK12 leads to early cancer-like changes and enhances cancer cell growth when combined with mutations in other genes like Trp53, while it inhibits tumor growth in the absence of another tumor suppressor gene, Pten.
  • CDK12 loss causes genomic instability and makes tumors sensitive to treatments targeting another protein, CDK13, highlighting CDK12 as a crucial tumor suppressor and suggesting new therapeutic approaches for CDK12-mutant mCRPC.
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  • Liangpingyou pomelo has a unique numbing aftertaste that researchers sought to understand, ruling out Sichuan pepper compounds as the cause.
  • Through testing pomelo peel juice, three coumarins—meranzin hydrate, isomeranzin, and marmin—were identified as responsible for the numbing sensation.
  • Sensory analysis confirmed specific concentration thresholds for numbness and other tastes, and molecular docking indicated that these coumarins interact with certain taste receptors (TRPV1, TPRA1, KCNK3).
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Misfolding and amyloid fibrillogenesis of proteins have close relationships with several neurodegenerative diseases. The present work investigates the inhibitive activities of ankaflavin (AK) and monascin (MS), two yellow pigments separated from -fermented rice, on hen egg white lysozyme (HEWL) fibrillation. The results demonstrated that AK/MS suppressed HEWL fibrillation through interfering with the nucleation period and AK was more potent.

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  • NPRL2, a tumor suppressor, is often downregulated in glioma, leading to aggressive tumor growth and unclear interactions with immune cells.
  • The study investigates how NPRL2 influences the degradation of Galectin-3 (Gal-3) via TRIM16, affecting immune cell functions and copper uptake in CD8T lymphocytes.
  • Results show that NPRL2 enhances TRIM16 expression and reduces Gal-3 levels, which improves CD8T cell recruitment and protects them from Gal-3-related damage, suggesting a potential therapeutic target for restoring immune function in glioma.
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  • - The high cost of vanadium electrolytes in vanadium flow batteries (VFBs) is largely due to slow chemical reactions; understanding these reactions through density functional theory can help improve them.
  • - Using catalytic site engineering, researchers designed iron single-atoms embedded in nitrogen-doped carbon nanotubes to enhance reaction speeds and decrease energy consumption when using vanadium electrolytes.
  • - The new method showed significantly improved reaction rates, reducing energy costs by 22.5%, while also producing high-quality vanadium electrolytes with minimal impurities.
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Background: The trend of postponing childbearing age is prevalent worldwide. Advanced paternal age (APA) is associated with adverse pregnancy outcomes and offspring health. However, the underlying mechanism by which paternal aging affects the risk of offspring neuropsychiatric disorders is unclear.

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Presently, multi-label classification algorithms are mainly based on positive and negative logical labels, which have achieved good results. However, logical labeling inevitably leads to the label misclassification problem. In addition, missing labels are common in multi-label datasets.

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  • The study addresses the challenge of functionalizing metal-organic frameworks (MOFs) to improve their ability to adsorb trace levels of benzene.
  • Researchers report that MFM-68-Cl, a zirconium-based MOF with chloro groups, shows a remarkable benzene uptake of 4.62 mmol/g at 298 K and 0.12 mbar.
  • The enhanced adsorption is attributed to unique interactions between chloro groups and benzene, along with optimal pore size and linker flexibility, marking a significant advancement in this area of research.
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Two small fragment translocation lines (T4DS·4DL-4EL and T5AS·5AL-4EL) showed high resistance to stripe rust and resistance gene Yr4EL was localized to an about 35 Mb region at the end of chr arm 4EL. Stripe rust, caused by the fungus Puccinia striiformis f. sp.

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While a range of characterisation techniques are available to probe CO adsorption processes, inelastic neutron scattering is scarcely used, primarily due to the reliance on hydrogeneous modes. Materials capable of adsorbing CO, such as solid supported-amines contain a range of C-H and N-H species, which can be probed to explore the adsorption of CO. Here we show the benefits of using inelastic neutron spectroscopy to probe CO adsorption with solid supported-amines, and the complementarity that can be achieved using different world-leading spectrometers.

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  • The study conducted a bibliometric analysis to assess the literature on inflammatory responses post-spinal cord injury, identifying research trends and emerging areas of focus.
  • A total of 2504 articles were reviewed, showing a steady increase in publications, with key contributions from China and the United States, and significant works from the Journal of Neurotrauma.
  • Future research is expected to delve into cellular autophagy and vesicular transport, highlighting the need for interdisciplinary collaboration and clinical trials to enhance treatments for spinal cord injuries.
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Introduction: In guidance published in February 2020, the FDA described their intent to prioritize enforcement against the sale of flavored cartridge-based Electronic Nicotine Delivery Systems (ENDS) except tobacco and menthol flavors. This guidance was specific to cartridge-based ENDS and did not apply to other ENDS types or e-liquids sold in the U.S.

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Biodegradable plastics (BPs) are presenting new challenges for their reutilization. This work found that volatile fatty acids (VFAs) production by co-fermentation of BPs with waste activated sludge (WAS) reached 4-37 times of the WAS fermentation alone, which was further amplified by pH regulation (especially alkaline regulation). Moreover, the VFAs composition is highly associated with BPs category.

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Background: Minimal residual disease (MRD) testing is a promising approach to tailor the treatment of multiple myeloma (MM). However, several major concerns remain to be addressed before moving it into daily practice, most of which stem from the dynamic nature of the MRD status. Thus, it is crucial to understand the MRD dynamics and propose its clinical implications.

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