Numerical analysis of soil deformation in the excavation with loose sand retained by inclined retaining piles.

Taking the conducted model test by authors as the research object, this paper first carries out detailed numerical analysis and verifies the reliability of the established model. Furthermore, the test phenomenon is explained based on numerical analysis, while parameter analysis is carried out, which mainly includes soil deformation between piles and soil deformation inside and outside excavation. The research results show that when the inclination angle of the piles is small (such as 10°), all or most of the soil (the range of the pile top to 0.

Clinical Manifestation, mNGS Based Diagnosis and Treatment of Pulmonary Mucormycosis with in a Diabetic Patient.

Pulmonary mucormycosis is a severe and often fatal disease that commonly affects patients with underlying conditions, such as diabetes. Early diagnosis and appropriate treatment are crucial for improving survival rates. However, clinical diagnosis remains challenging due to difficulty in obtaining etiological evidence.

Safety and environmental impact control of cross passage construction in soft soil strata using tunnel boring machine method.

The construction of cross passages using the tunnel boring machine (TBM) method represents an emerging construction technique with numerous advantages. However, owing to the scarcity of application instances, the safety control methodologies and the regulatory patterns concerning environmental impacts remain inconclusive. In this study, a cross passage excavated using the TBM method-the first of its kind in the Tianjin area-was investigated.

Furosemide improves the stone clearance rate of extracorporeal shockwave lithotripsy for kidney stones but not ureteral stones: a systematic review and meta-analysis.

Introduction: We conducted a meta-analysis (MA) to investigate the effects of furosemide on the prognosis of extracorporeal shockwave lithotripsy (SWL) therapy to remove renal (RS) and ureteric stones (US).

Methods: We screened scientific databases including PubMed, Clinicalkey, Google Scholar, Medline, Embase, and Cochrane, from the date of establishment until March 2022, to search for randomized controlled trials evaluating SWL, in combination with furosemide (experimental group) or with SWL alone (control group), in treating RS or US. Our search terms included furosemide, extracorporeal SWL, and urolithiasis.

Image-based promoter prediction: a promoter prediction method based on evolutionarily generated patterns.

Prediction of promoter regions is crucial for studying gene function and regulation. The well-accepted position weight matrix method for this purpose relies on predefined motifs, which would hinder application across different species. Here, we introduce image-based promoter prediction (IBPP) as a method that creates an "image" from training promoter sequences using an evolutionary approach and predicts promoters by matching with the "image".

Knockdown of S-phase kinase-associated protein-2 expression in MCF-7 inhibits cell growth and enhances the cytotoxic effects of epirubicin.

S-phase kinase-associated protein-2 (Skp2) plays a key role in ubiquitin-mediated proteolysis, resulting in the progression of cells from a quiescent to a proliferative state. Skp2 is overexpressed in a variety of tumors and inversely correlated with p27 expression, including breast cancer. In this study, we used small interfering RNAs (siRNAs) to inhibit Skp2 expression in human breast cancer MCF-7 cells and thereby investigate if knockdown of Skp2 by RNA interference (RNAi) would inhibit breast cancer cell growth and influence the effects of epirubicin on MCF-7 cells.