Collaborative learning with corrupted labels.

Deep neural networks (DNNs) have been very successful for supervised learning. However, their high generalization performance often comes with the high cost of annotating data manually. Collecting low-quality labeled dataset is relatively cheap, e.

Traditional Classification and Novel Subtyping Systems for Bladder Cancer.

Bladder cancer is the most common tumor in the urinary system, with approximately 420,000 new cases and 160,000 deaths per year. The European Organization for Research and Treatment of Cancer (EOTRC) classifies non-muscular invasive bladder cancer (NMIBC) into low-risk, medium-risk and high-risk groups based on a comprehensive analysis of NMIBC pathological parameters and the risk of recurrence and progression to muscular invasive bladder cancer (MIBC). Traditional classification systems are based on pathologic grading, staging systems, and clinical prognosis.

Human Fall Detection Based on Body Posture Spatio-Temporal Evolution.

Abnormal falls in public places have significant safety hazards and can easily lead to serious consequences, such as trampling by people. Vision-driven fall event detection has the huge advantage of being non-invasive. However, in actual scenes, the fall behavior is rich in diversity, resulting in strong instability in detection.

Comparison of severity index and plasma paraquat concentration for predicting survival after paraquat poisoning: A meta-analysis.

Background: Severity index and plasma paraquat (PQ) concentration can predict the prognosis of patients with PQ poisoning. However, the better parameter is yet to be systematically investigated and determined. Thus, we conduct this systematic review and meta-analysis to investigate the prognostic value of severity index and plasma PQ concentration in patients with PQ poisoning.

Evodiamine reduced peripheral hypersensitivity on the mouse with nerve injury or inflammation.

Management of chronic pain is still hard, and new analgesic drugs are needed. Evodiamine (Evo) and rutaecarpine (Rut) are two major active components of Evodia rutaecarpa, a Chinese traditional medicine that has been used as an analgesic for a long time. However, their effects on peripheral hypersensitivity remain unknown.

Associations between Maternal Lipid Profiles and Pregnancy Complications: A Prospective Population-Based Study.

Objective: To investigate whether plasma lipid profiles are independently associated with pregnancy complications including gestational diabetes mellitus (GDM), hypertensive disorder complicating pregnancy (HDCP), and intrahepatic cholestasis of pregnancy (ICP).

Study Design: A prospective study was conducted among 1,704 pregnant women at three medical institutions in Chengdu, China. The concentrations of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured at gestational weeks 12 ± 1, 24 ± 1, and 34 ± 1.

Vertical profiling of fine particulate matter and black carbon by using unmanned aerial vehicle in Macau, China.

An unmanned aerial vehicle (UAV) equipped with miniature monitors was used to study the vertical profiles of PM (particulate matter with a ≤2.5-μm diameter) and black carbon (BC) in Macau, China, from the surface to 500 m above ground level (AGL). Twelve- and 11-day measurements were conducted during February and March 2018, respectively.

Procalcitonin for predicting catheter-associated bloodstream infection: A meta-analysis.

Objective: The predictive accuracies of procalcitonin (PCT) in the diagnosis of catheter-associated bloodstream infection (CABSI) vary widely. This meta-analysis aimed to explore the predictive value of PCT for CABSI.

Methods: We searched PubMed, EMBase, Web of Science, ScienceDirect, Cochrane Library, and studies published up to 10 March 2019.

MiR-129-5p promotes docetaxel resistance in prostate cancer by down-regulating CAMK2N1 expression.

This study focuses on the effect of miR-129-5p on docetaxel-resistant (DR) prostate cancer (PCa) cells invasion, migration and apoptosis. In our study, the expression of CAMK2N1 was assessed by qRT-PCR in PCa patient tissues and cell lines including PC-3 and PC-3-DR. Cells transfected with miR-129-5p mimics, inhibitor, CAMK2N1 or negative controls (NC) were used to interrogate their effects on DR cell invasions, migrations and apoptosis during docetaxel (DTX) treatments.

PPAR /Nnat/NF-B Axis Involved in Promoting Effects of Adiponectin on Preadipocyte Differentiation.

A previous study has demonstrated that adiponectin (APN) could promote preadipocyte differentiation, and the present study further explored its mechanism. 3T3-L1 cells were infected with adenovirus holding human adiponectin gene apM1 and mouse neuronatin (Nnat) shRNA and initiated differentiation while coculturing with mature adipocytes stimulated with LPS. After 8 days, preadipocyte differentiation was observed by Oil Red O staining.

Concordance of chronic conditions among the household members in Shanghai: a cross-sectional study.

Objectives: Members living in the same household tend to share some similar behaviours and environment. We want to quantitatively assess the associations of chronic conditions to investigate the concordance of disease status among the household members.

Setting: Shanghai, China.

A hybrid machine learning approach to cerebral stroke prediction based on imbalanced medical dataset.

Background And Objective: Cerebral stroke has become a significant global public health issue in recent years. The ideal solution to this concern is to prevent in advance by controlling related metabolic factors. However, it is difficult for medical staff to decide whether special precautions are needed for a potential patient only based on the monitoring of physiological indicators unless they are obviously abnormal.

Yeast diversity investigation of Vitis davidii Föex during spontaneous fermentations using culture-dependent and high-throughput sequencing approaches.

Vitis davidii Föex is widely planted in South China as a potential wine making grape. In this study, yeast communities during the spontaneous fermentations of two varieties of Vitis davidii Föex in Guizhou, China were investigated. Hanseniaspora uvarum, Pichia terricola, Saccharomyces cerevisiae/S.

Comparison of In-Hospital Mortality and Length of Stay in Acute ST-Segment-Elevation Myocardial Infarction Among Urban Teaching Hospitals in China and the United States.

Background The aim of the study is to compare in-hospital outcomes of acute ST-segment-elevation myocardial infarction (STEMI) between China and the United States. Methods and Results Urban teaching hospitals were queried for adult patients with a primary diagnosis of acute STEMI during 2007-2010. The primary outcome was in-hospital mortality, and the secondary outcome was length of stay.

Flaxseed oil supplementation improves intestinal function and immunity, associated with altered intestinal microbiome and fatty acid profile in pigs with intrauterine growth retardation.

Flaxseed oil (FO), enriched in n-3 polyunsaturated fatty acids (PUFAs), is an important oil source for intestinal development and health. We aimed to study the different effects of FO versus soybean oil (SO) on growth, intestinal health and immune function of neonates with intrauterine growth retardation (IUGR) using a weaned piglet model. Forty pairs of male IUGR and normal birth weight piglets, weaned at 21 ± 1 d, were fed diets containing either 4% FO or SO for 3 weeks consecutively.

Continuous theta burst stimulation provides neuroprotection by accelerating local cerebral blood flow and inhibiting inflammation in a mouse model of acute ischemic stroke.

Acute ischemic stroke is a leading cause of disability with limited therapeutic options. Continuous theta burst stimulation (cTBS) has recently been shown to be a promising noninvasive therapeutic strategy for neuroprotection in ischemic stroke patients. Here, we investigated the protective effects of cTBS following acute infarction using a photothrombotic stroke (PTS) model in the right posterior parietal cortex (PPC) of C57BL/6 mice.

Biomechanical and neuromuscular strategies on backward somersault landing in artistic gymnastics: A case study.

Landing is a crucial factor in gymnastics competitions, but the underlying biomechanical and neuromuscular strategies remains unclear. This study aimed to investigate the biomechanical characteristics and neuromuscular strategies of landing for backward somersault. A 19-segment human model was developed and bilateral lower-limb joint loadings were estimated using computer stimulation.

Skin/Muscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice.

Background: Surgery is a frequent cause of persistent pain. Unrelieved chronic postsurgical pain causes unnecessary patient suffering and discomfort and usually leads to psychological complications. The rat model of skin/muscle incision and retraction (SMIR) with decreased paw withdrawal thresholds developed by Flatters was usually used to investigate the underlying mechanism of chronic postsurgical pain.

PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer.

Purpose: In this study, we addressed the underlying mechanisms for the association between enzalutamide (ENZ) treatment and neuroendocrine prostate cancer (NEPC), and the critical involvement of MYCN, and loss of RB1 function in neuroendocrine differentiation (NED) of prostatic epithelial cells, and the development of NEPC. We further sought to determine whether PARP inhibition could suppress NEPC, and to identify molecular determinants of this therapeutic activity.

Experimental Design: We used a novel prostate cancer patient-derived xenograft (PDX) treatment model, prostatic adenocarcinoma and NEPC cell lines, an NEPC organoid line, and NEPC xenograft models to address the mechanistic basis of ENZ-induced NED, and to analyze suppression of NED and NEPC growth by PARP inhibition.

eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons.

Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and plays an important role in regulating gene expression levels. A major role of codon usage is thought to regulate protein expression levels by affecting mRNA translation efficiency, but the underlying mechanism is unclear. By analyzing ribosome profiling results, here we showed that codon usage regulates translation elongation rate and that rare codons are decoded more slowly than common codons in all codon families in Neurospora.

Effects of Pre-Cardiopulmonary Bypass Administration of Dexmedetomidine on Cardiac Injuries and the Inflammatory Response in Valve Replacement Surgery With a Sevoflurane Postconditioning Protocol: A Pilot Study.

Background: Preventing myocardial ischemia-reperfusion injury in on-pump cardiac surgeries remains an enormous challenge. Sevoflurane postconditioning has been effective at overcoming this challenge by modulating inflammatory mediators and ameliorating antioxidative stress. Dexmedetomidine (DEX) is a commonly used medication for cardiac patients with organ-protective properties that lead to positive outcomes.

DNA co-methylation analysis of lincRNAs across nine cancer types reveals novel potential epigenetic biomarkers in cancer.

The potential functions and prognostic value of lincRNAs with co-methylation events are explored in 9 cancer types. Here, we evaluated the co-methylation events in promoter and gene-body regions between two lincRNAs across 9 cancer types by constructing a systematic biological framework. The co-methylation events in both promoter and gene-body regions tended to be highly cancer specific.

Correlations between ultrasonographic and subsequent radiographic findings of developmental dysplasia of the hips.

Purpose: The study aimed to investigate the utility of ultrasonographic findings in predicting the subsequent radiographic parameters of developmental dysplasia of the hips.

Methods: In this 12-year retrospective cohort study, all new-born infants with a positive clinical examination or risk factors were included. They were scheduled for hip ultrasonography in the first 3 months, and subsequent radiographs at 1 year of life.

A Graph Embedding Framework for Maximum Mean Discrepancy-Based Domain Adaptation Algorithms.

Domain adaptation aims to deal with learning problems in which the labeled training data and unlabeled testing data are differently distributed. Maximum mean discrepancy (MMD), as a distribution distance measure, is minimized in various domain adaptation algorithms for eliminating domain divergence. We analyze empirical MMD from the point of view of graph embedding.